Pharmaceutical/food grade titanium dioxide particles are absorbed into the bloodstream of human volunteers

Particle and Fibre Toxicology
Laetitia C PeleJonathan J Powell

Abstract

Exposure to persistent engineered nano and micro particles via the oral route is well established. Animal studies have demonstrated that, once ingested, a small proportion of such particles translocate from the gastrointestinal tract to other tissues. Exposure to titanium dioxide is widespread via the oral route, but only one study has provided indirect evidence (total titanium analyses) of absorption into the blood stream in humans. We sought to replicate these observations and to provide additional evidence for particulate uptake. Human volunteers with normal intestinal permeability were orally administered 100 mg pharmaceutical/food grade titanium dioxide. Blood samples were collected from 0.5 to 10 h post ingestion and analysed for the presence of reflectant bodies (particles) by dark field microscopy, and for total titanium by inductively coupled plasma mass spectrometry (ICP-MS). Blood film analyses implied early absorption of particles (2 h) with a peak maximum at 6 h following ingestion. The presence of these reflectant particles in blood roughly mirrored the levels of total titanium by ICP-MS, providing good evidence for the latter being a measure of whole particle (titanium dioxide) absorption. This study shows that a...Continue Reading

References

Jan 1, 1987·Human Pathology·N A ShepherdD A Levison
May 11, 2002·The Proceedings of the Nutrition Society·Miranda C E LomerJonathan J Powell
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Myoung Ho JangHiroshi Kiyono
Dec 23, 2004·The British Journal of Nutrition·Miranda C E LomerJonathan J Powell
Jun 10, 2008·Analytical and Bioanalytical Chemistry·Alejandro Sarmiento-GonzálezAlfredo Sanz-Medel
Sep 13, 2008·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·V ThoreeJ J Powell
Oct 25, 2008·Analytical and Bioanalytical Chemistry·Alejandro Sarmiento-GonzálezAlfredo Sanz-Medel
Jan 26, 2010·Journal of Autoimmunity·Jonathan J PowellLaetitia C Pele
Sep 6, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Aziz AwaadKazunori Ishimura
Nov 29, 2011·Toxicology·Eleonore Fröhlich, Eva Roblegg
Dec 3, 2013·Analytical and Bioanalytical Chemistry·Anne-Lena FabriciusThomas A Ternes
Mar 29, 2014·Particle and Fibre Toxicology·Emilie BrunMarie Carrière
Jun 17, 2014·Journal of Agricultural and Food Chemistry·Ruud J B PetersHans Bouwmeester
Aug 6, 2014·Integrated Environmental Assessment and Management·Boris Jovanović
Oct 16, 2014·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Zhoumeng LinJim E Riviere
Nov 11, 2014·Beilstein Journal of Nanotechnology·Ralf TheissmannThomas Koch

❮ Previous
Next ❯

Citations

May 29, 2016·Mutation Research. Reviews in Mutation Research·Laetitia Gonzalez, Micheline Kirsch-Volders
Mar 23, 2017·ACS Applied Materials & Interfaces·Anqi SunXiangang Hu
May 27, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Hans BouwmeesterMark A Jepson
Feb 6, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Maria Grazia AmmendoliaBarbara De Berardis
Jan 30, 2020·Nanotoxicology·Ruud J B PetersMartijn van der Lee
Apr 13, 2018·Particle and Fibre Toxicology·M B HeringaH Bouwmeester
Jun 3, 2018·Journal of Nanobiotechnology·Hans Christian WinklerHanspeter Naegeli
Sep 25, 2017·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Rachel E HewittJonathan J Powell
Oct 19, 2020·Central European Journal of Public Health·Daniela PelclováŠtěpánka Vlčková
Oct 11, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Estefany I Medina-ReyesJosé Pedraza-Chaverri
Oct 18, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Estefany I Medina-ReyesJosé Pedraza-Chaverri
Sep 29, 2019·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Marie DorierMarie Carriere
Apr 27, 2021·Frontiers in Nutrition·Dipendra Kumar MahatoPradeep Kumar
May 13, 2021·Scientific Reports·Kristóf HegedüsPeter Hantz
May 13, 2021·EFSA Journal·UNKNOWN EFSA Panel on Food Additives and Flavourings (FAF)Matthew Wright
Jun 28, 2019·Chemical Research in Toxicology·Adam HellerKeith A Friedman
Apr 3, 2020·Chemical Research in Toxicology·William K Boyes, Christoph van Thriel
May 10, 2020·Chemical Research in Toxicology·Angela A M KämpferRoel P F Schins
May 25, 2018·Chemical Research in Toxicology·Adam HellerSheryl S Coffman

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.