Pharmaco-economic analysis of adjuvant chemotherapy for stage II and III colorectal cancer

Molecular and Clinical Oncology
Mina IwaiHitomi Teramachi

Abstract

Comparison of the costs of capecitabine plus oxaliplatin (CapeOX) with that of FOLFOX6 (5-fluorouracil/leucovorin [LV] + oxaliplatin) as an adjuvant chemotherapy for stage II or III colorectal cancer has previously been reported. However, there are no reports comparing uracil and tegafur (UFT)/LV with capecitabine. Therefore, the current study compared the costs of adjuvant chemotherapy regimens including CapeOX, FOLFOX6, capecitabine and UFT/LV. The costs of chemotherapeutic drugs and for the prevention and treatment of adverse events were evaluated, as these account for the bulk of the treatment costs. Costs were expressed in Japanese Yen (US dollars). The mean costs of the chemotherapeutic drugs per patient, for an entire course of treatment, were ¥882,632 ($8,406) for UFT/LV, ¥353,290 ($3,365) for capecitabine, ¥1,436,218 ($13,678) for FOLFOX6 and ¥1,255,630 ($11,958) for CapeOX. The mean costs associated with adverse events per patient were ¥2,210 ($21) for UFT/LV, ¥6,749 ($64) for capecitabine, ¥173,432 ($1,652) for FOLFOX6 and ¥107,430 ($1,023) for CapeOX. Therefore, the capecitabine regimen contributes to reducing costs for the management of patients with colorectal cancer who have had surgery.

References

Jun 4, 2004·The New England Journal of Medicine·Thierry AndréUNKNOWN Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC)
Jul 1, 2005·The New England Journal of Medicine·Chris TwelvesWerner Scheithauer
Feb 14, 2009·Current Medical Research and Opinion·Nikos ManiadakisGeorge Fountzilas
Mar 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel G HallerHans-Joachim Schmoll
Mar 20, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Q XieQ Li
Dec 31, 2014·World Journal of Gastroenterology : WJG·Feng WenQiu Li
Mar 19, 2015·International Journal of Clinical Oncology·Toshiaki WatanabeUNKNOWN Japanese Society for Cancer of the Colon and Rectum

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