Pharmaco-EEG profiles of antidepressants. Pharmacodynamic studies with fluvoxamine

British Journal of Clinical Pharmacology
B SaletuP Rajna

Abstract

1 Antidepressant drugs produce significant changes in human brain function as reflected in the quantitatively analysed EEG. Two main types of pharmaco-EEG profiles may be differentiated: a thymeretic (desipramine-like) profile characterised mainly by an alpha increase suggesting activating properties and a thymoleptic (imipramine- or amitriptyline-like) profile showing a concomitant increase of slow and fast activities and a decrease in alpha activity indicating also sedative qualities. A small number of compounds exhibit still different profiles. 2 Aside from determining the type of EEG changes, the pharmaco-EEG method seems to be of value in determining time and dose efficacy relations at the target organ, the human brain. Moreover, the relationships between pharmacodynamics and pharmacokinetics may be determined. 3 Fluvoxamine, a selective 5-hydroxytryptamine (5-HT) re-uptake inhibitor from the new class of 2-aminoethyloximethers of aralkylketones, produced a typical thymoleptic pharmaco-EEG profile after oral doses of 75 mg in a double-blind placebo-controlled study involving 10 healthy volunteers. Fluvoxamine (75 mg) induced less augmentation of slow activity than 75 mg imipramine, indicating less sedative properties of fl...Continue Reading

Citations

Jan 1, 1992·European Journal of Clinical Pharmacology·S R FlettC M Bradshaw
Jan 1, 1988·European Journal of Clinical Pharmacology·A PatatJ Granier
Jan 1, 1991·Biological Psychiatry·D J KupferA B McEachran
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·D RothD V Sheehan
Feb 1, 1994·British Journal of Clinical Pharmacology·A PatatL A Court
Feb 5, 2002·CNS Drugs·Susan M Cheer, David P Figgitt
Jun 3, 2014·BioMed Research International·Katherine HerronAnnette Sterr
Mar 19, 2014·Bipolar Disorders·Annamaria PainoldDietrich Lehmann
Jul 28, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·O ArnoldG M Saletu-Zyhlarz
Jun 1, 1989·Neurophysiologie clinique = Clinical neurophysiology·P BaudC Sebban
Oct 31, 2002·Human Psychopharmacology·Alain Patat
Nov 17, 2010·Clinical EEG and Neuroscience·B SaletuG M Saletu-Zyhlarz
Jan 1, 1989·Acta Psychiatrica Scandinavica. Supplementum·G R McClellandD Jackson
Apr 22, 2005·British Journal of Clinical Pharmacology·G J H DumontUNKNOWN Biomarker Working Group of the German Association for Applied Human Pharmacology
Oct 1, 1994·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·A J Flint

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