Pharmaco-toxicological study of Kageneckia oblonga, Rosaceae

Zeitschrift Für Naturforschung. C, a Journal of Biosciences
Carla DelporteN Backhouse

Abstract

The probable antipyretic, antiinflammatory, analgesic and antioxidant properties of Kageneckia oblonga, Rosaceae, were investigated and the major compounds of its active extracts were isolated. The study comprised the acute toxicity of the extracts of global methanol, hexane, dichloromethane and methanol. The cytotoxicity of global methanol extract was studied in three tumoral cell lines. All the extracts exhibited the pharmacological activities under study. Methanol and dichloromethane were the most toxic extracts. From the global methanol extract, isolations were performed of prunasin, 23,24- dihydro-cucurbitacin F, and a new cucurbitacin, 3beta-(beta-D-glucosyloxy)-16alpha,23alpha-epoxycucurbita-5,24-diene-11-one. The cytotoxicity of both cucurbitacins on human neutrophils at the assayed concentrations was not statistically significant. In-vitro assays showed that both cucurbitacins can be partly responsible for the analgesic, antipyretic, and anti-inflammatory activities. Evaluation was done of the cytotoxicity of global methanol extract, 23, 24-dihydrocucurbitacin F, aqueous extracts and prunasin against P-388 murine leukaemia, A-549 human lung carcinoma and HT-29 colon carcinoma. Since global methanol extract presented a ...Continue Reading

Citations

Jan 1, 2008·Journal of Ethnopharmacology·N BackhouseC Delporte
May 23, 2006·Journal of Ethnopharmacology·Silvia ErazoNadine Backhouse
Apr 26, 2005·Journal of Ethnopharmacology·C DelporteO Muñoz
Jun 25, 2002·The Journal of Pharmacy and Pharmacology·Gabriela Egly FeresinGuillermo Schmeda-Hirschmann
Jul 7, 2011·International Journal of Molecular Sciences·Gedson Rodrigues de Morais LimaLeônia Maria Batista

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