Pharmacodynamic and clinical efficacy of reduced ticagrelor maintenance doses in patients with coronary artery disease.

Current Medical Research and Opinion
Piotr AdamskiJacek Kubica

Abstract

An increasing body of data indicates that a reduction of ticagrelor maintenance dose (MD) in stabilized patients might improve ticagrelor's safety profile and adherence to the treatment. The aim of this review was to discuss the rationale and summarize the current pharmacodynamic and clinical outcomes-based evidence from reduced MD of ticagrelor in patients with coronary artery disease (CAD). A narrative systematic review based on a literature search using the PubMed database from its inception through to June 2020. A search strategy included a combination of relevant search terms regarding ticagrelor reduced MD. The pre-determined inclusion criteria were: (1) randomized or observational trials; (2) presentation of clinical or pharmacodynamic results; (3) evaluation of any ticagrelor MD below 90 mg BID in patients with CAD. Studies evaluating the following ticagrelor reduced MD have been identified: 90 mg QD, 60 mg BID, 60 mg QD, 45 mg BID, 22.5 mg BID. Majority of trials assessing doses <60 mg BID were performed in Asian patients only. Antiplatelet effect of ticagrelor in CAD decreases with the dose, however even reduced MDs provide sufficient platelet inhibition, which is greater than in clopidogrel-treated patients. De-escal...Continue Reading

References

Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Sep 1, 2009·The New England Journal of Medicine·Lars WallentinMona Thorsén
Jul 21, 2010·British Journal of Clinical Pharmacology·Kathleen Butler, Renli Teng
Jun 18, 2014·Cardiovascular Intervention and Therapeutics·Y HiasaH Emanuelsson
Mar 17, 2015·The New England Journal of Medicine·Marc P BonacaUNKNOWN PEGASUS-TIMI 54 Steering Committee and Investigators
Mar 12, 2016·Journal of the American College of Cardiology·Robert F StoreyMarc S Sabatine
Oct 14, 2017·Journal of the American College of Cardiology·Dimitrios AlexopoulosPeriklis Davlouros
Oct 19, 2017·European Heart Journal. Cardiovascular Pharmacotherapy·Jacek KubicaEliano P Navarese
Apr 7, 2018·Journal of the American College of Cardiology·Duk-Woo ParkSeung-Jung Park
Aug 31, 2018·European Heart Journal·Franz-Josef NeumannUNKNOWN ESC Scientific Document Group
Dec 21, 2018·Journal of the American Heart Association·Marc P BonacaMarc S Sabatine
Jun 21, 2019·European Heart Journal. Cardiovascular Pharmacotherapy·Mikael DellborgMarc S Sabatine
Sep 11, 2019·European Heart Journal·Juhani KnuutiUNKNOWN ESC Scientific Document Group
Sep 27, 2019·The New England Journal of Medicine·Roxana MehranC Michael Gibson
Dec 19, 2019·Frontiers in Cardiovascular Medicine·Małgorzata OstrowskaJolanta M Siller-Matula

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