PMID: 11318075Apr 25, 2001Paper

Pharmacodynamic and pharmacokinetic properties of a premixed 85/15 human insulin preparation

Clinical Therapeutics
S R MudaliarR R Henry

Abstract

Many patients with diabetes use mixtures of fast-acting (regular human) insulin and intermediate-acting (neutral protamine Hagedorn [NPH]) insulin to control their blood glucose levels. Premixed insulin is available in a 70%/30% mixture and a 50%/50% mixture of NPH/regular human insulin. For some patients, however, a premixed formulation containing > or =30% regular human insulin can provide too much fast-acting insulin, potentially causing an increased risk for hypoglycemia in the early hours after injection. The pharmacokinetic and pharmacodynamic properties of a premixed formulation of 85% NPH insulin and 15% regular human insulin (85/15) were compared with those of a premixed 70%/30% NPH/regular human insulin preparation and 100% NPH insulin. A 12-hour euglycemic clamp approach was used to assess glucose-lowering effects and serum insulin levels in 36 healthy male volunteers in a single-dose (0.5 U/kg), randomized, double-blind, 3-period, crossover study. From 0 to 8 hours after injection, the glucose-lowering effects and serum insulin levels for the 85/15 premixed insulin preparation were significantly greater than those for NPH insulin (P < or = 0.05) but significantly less than those for the 70/30 premixed insulin prepar...Continue Reading

References

Aug 1, 1991·Diabetes Research and Clinical Practice·S N DavisK G Alberti
Jan 1, 1985·Endocrine Reviews·R N BergmanM Ader

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Citations

May 27, 2004·Drugs·William T Cefalu

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