Pharmacodynamic assessment of dihydroxyprogesterone acetophenide plus estradiol enanthate as a monthly injectable contraceptive

Contraception
R RecioG Perez-Palacios

Abstract

The pharmacodynamics of the combination of dihydroxyprogesterone acetophenide (DHPA) and estradiol enanthate (E2-EN) following its intramuscular administration at two doses were studied in 16 healthy women of reproductive age. Subjects were randomly allocated in two groups: group I (n = 9) received the combination DHPA 150 mg + E2-EN 10 mg on three consecutive monthly injections, while group II (n = 7) received half-dose of the same formulation. Ovarian function and endometrial bleeding patterns were investigated in all participants for one pre-treatment cycle, three treatment intervals and two post-treatment cycles. The results disclosed that ovulation was inhibited for at least 30 days following DHPA/E2-EN administration in all participants from both groups. The circulating estradiol levels 30 days after last injection were slightly elevated as compared with those observed in normal early follicular phase. Return to ovulatory cycles was documented within 90 days after treatment. The length of the bleeding-free intervals during treatment was shortened in both groups, particularly in group II. No significant changes in HDL-cholesterol levels were observed throughout the study. It is envisaged however, that large modification of...Continue Reading

References

Jun 1, 1977·Obstetrical & Gynecological Survey·M Toppozada
Nov 1, 1985·Journal of Steroid Biochemistry·M A Vázquez-AlcántaraJ Garza-Flores
Jul 1, 1967·British Journal of Preventive & Social Medicine·T Khosla, C R Lowe

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Citations

Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·J Garza-FloresG Perez-Palacios
May 1, 1988·Contraception·J Garza-FloresV Díaz-Sanchez
Apr 1, 1994·Contraception·J Garza-Flores
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Maria F GalloCatherine d'Arcangues
Jan 1, 1994·Journal of Obstetrics and Gynaecology·J R NewtonP E Hall

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