Pharmacodynamic assessment of diuretic efficacy and braking in a furosemide continuous infusion model

Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology
Darcy B AdinM Papich

Abstract

Diuretic failure is a potential life-ending event but is unpredictable and poorly understood. The objectives of this study were to evaluate pharmacodynamic markers of furosemide-induced diuresis and to investigate mechanisms of diuretic braking in dogs receiving constant rate infusion (CRI) of furosemide. Six healthy male dogs. Raw data and stored samples from one arm of a previously published study were further analyzed to mechanistically investigate causes of diuretic braking in these dogs. Urine volume was recorded hourly during a 5-h furosemide CRI. Urine and blood samples were collected hourly to measure serum and urine electrolytes, urine aldosterone, and plasma and urine furosemide. Serum electrolyte fractional excretion was calculated. Urine sodium concentration was indexed to urine potassium (uNa:uK) and urine furosemide (uNa:uFur) concentrations, plasma furosemide concentration was indexed to urine furosemide concentration (pFur:uFur), and urine aldosterone was indexed to urine creatinine (UAldo:C). Temporal change and the relationship to urine volume were evaluated for these measured and calculated variables. Urine volume was significantly correlated with urine electrolyte amounts and with uNa:uK. The ratio of pFur:u...Continue Reading

Citations

Apr 12, 2019·Journal of Veterinary Internal Medicine·Bruce W KeeneMasami Uechi
Dec 12, 2020·Journal of Veterinary Internal Medicine·Darcy AdinBruna Del Nero

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