PMID: 9174206Jun 1, 1997Paper

Pharmacodynamic effects of amoxicillin versus cefotaxime against penicillin-susceptible and penicillin-resistant pneumococcal strains: a phase I study

Antimicrobial Agents and Chemotherapy
Lorenzo AguilarJosé Prieto

Abstract

Serum bactericidal activity against a penicillin-susceptible strain and a penicillin-resistant strain of Streptococcus pneumoniae (amoxicillin and cefotaxime MICs, 0.001 and 1 microg/ml, respectively, and MBCs, 0.01 and 2 microg/ml, respectively) was measured in 12 healthy volunteers who each received an oral 875-mg dose of amoxicillin and an intramuscular 1-g dose of cefotaxime in a crossover fashion. The areas under the bactericidal activity-time curves for the two strains were found to be similar for both antibiotics despite the significantly higher (P < 0.002) AUC/MIC and peak level/MIC values for cefotaxime.

References

Jul 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P C Appelbaum
Apr 11, 1985·The New England Journal of Medicine·J S Wolfson, M N Swartz
Feb 1, 1974·The Journal of Infectious Diseases·J KlasterskyD Weerts
Aug 11, 1994·The New England Journal of Medicine·I R Friedland, G H McCracken
Mar 1, 1996·Antimicrobial Agents and Chemotherapy·M TrautmannP Koeppe

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Citations

Mar 25, 1998·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M L Gómez-LusL Aguilar
Dec 1, 1999·Infectious Disease Clinics of North America·B S Johnson

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