PMID: 9174189Jun 1, 1997Paper

Pharmacodynamic evaluation of a new glycopeptide, LY333328, and in vitro activity against Staphylococcus aureus and Enterococcus faecium

Antimicrobial Agents and Chemotherapy
R C MercierM J Rybak

Abstract

The objectives of the present study were to compare the in vitro activity of LY333328 (LY) to that of vancomycin (V) alone and in combination with gentamicin (G) and rifampin (R) against methicillin-resistant Staphylococcus aureus (MRSA) and V-resistant Enterococcus faecium (VREF), by using the killing curve methods. In addition, the effect of the inoculum size and protein on LY's activity was evaluated by using MICs and killing curves. MICs, MBCs, and killing curves were determined with supplemented Mueller-Hinton broth (B), B with albumin (4 g/dl) (A), and B with 50% pooled human serum (S). For MRSA, time to 99.9% killing after exposure to LY at four times the MIC (4x MIC) was achieved at 0.5 +/- 0 h (mean +/- standard deviation) and was significantly faster than that by V (8.54 +/- 0.10 h; P = 0.001). Against VREF, LY decreased the inoculum by 2.2 log10 CFU/ml at 24 h (P = 0.002). With a large inoculum of MRSA, the activity of LY and V at 4x MIC was decreased compared to that with the standard inoculum (P = 0.0003) and regrowth occurred at 24 h. The reduction in the number of CFU per milliliter at 24 h to 2 log10 CFU/ml was restored by increasing the LY concentration to at least 16x MIC. At 24 h, the combinations of LY and G...Continue Reading

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Citations

Jan 31, 2003·Expert Opinion on Investigational Drugs·Neil Woodford
Jun 16, 2005·Expert Review of Anti-infective Therapy·Renee-Claude Mercier, Lenka Hrebickova
Jan 31, 2008·Expert Opinion on Investigational Drugs·Garyphallia Poulakou, Helen Giamarellou
Feb 15, 2003·FEMS Microbiology Reviews·Norris E Allen, Thalia I Nicas
Apr 24, 2003·Antimicrobial Agents and Chemotherapy·Carole J BoylanThomas R Parr
Oct 13, 2007·Expert Opinion on Pharmacotherapy·Evelina Tacconelli, Maria A Cataldo
May 29, 2008·Future Microbiology·Jared Crandon, David P Nicolau
Dec 25, 2009·Pharmacotherapy·Michael T Guskey, Brian T Tsuji
Dec 25, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Lamis R KaraouiElias B Chahine
Mar 4, 2014·Nature Nanotechnology·Joseph W NdieyiraGabriel Aeppli
Nov 30, 2000·Current Infectious Disease Reports·M J Rybak, E A Coyle
Jan 11, 2005·Current Opinion in Infectious Diseases·Gregory M Anstead, Aaron D Owens
Mar 22, 2006·Expert Opinion on Investigational Drugs·Kristina E WardKerry L LaPlante
Apr 23, 2004·Drugs·Françoise Van BambekePaul M Tulkens
Oct 14, 2010·The Journal of Antibiotics·Céline VidaillacMichael J Rybak
Mar 28, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rodrigo E MendesRonald N Jones
Sep 16, 1998·Antimicrobial Agents and Chemotherapy·F García-GarroteE Bouza
Jul 27, 1999·British Journal of Clinical Pharmacology·K F Barker
Apr 29, 1998·Antimicrobial Agents and Chemotherapy·G W KaatzM J Rybak
Jun 3, 2021·Antibiotics·Javier Campanini-SalinasDavid Vásquez-Velásquez
Oct 12, 2000·Clinical Microbiology Reviews·Y CetinkayaC G Mayhall

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