Pharmacodynamic interaction between mefloquine and retinol in Plasmodium falciparum in vitro.

Wiener klinische Wochenschrift
Maria GruberWalther H Wernsdorfer

Abstract

Mefloquine, a 4-quinolinemethanol derivative, was introduced in Thailand after Plasmodium falciparum had acquired almost universal resistance to the 4-aminoquinolines and antifols. However, also resistance to mefloquine has become an increasing problem, but artemisinin-based combination therapy (ACT) with mefloquine and artesunate remained until recently sufficiently effective. Since synergistic interaction between quinine, another 4-quinolinemethanol, with retinol was observed earlier, the investigations were expanded to mefloquine. The interaction between mefloquine and retinol at concentrations equal to the 50(th), 65(th) and 80(th) percentile of the physiological retinol levels in healthy adults was determined in 37 fresh isolates of P. falciparum. The mean IC(50), IC(90) and IC(99) values for mefloquine were 1.76, 9.81 and 39.78 microM, those for mefloquine + retinol "low" 0.33, 1.37 and 4.33 microM, those for mefloquine + retinol "medium" 0.29, 1.15 and 3.48 microM, and those for mefloquine + retinol "high" 0.20, 0.85 and 2.70 microM. Evidence for strong synergism between mefloquine and retinol in P. falciparum was highly significant.

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Citations

Oct 7, 2010·Wiener klinische Wochenschrift·Gerwald KerschbaumerWalther H Wernsdorfer
Oct 7, 2010·Wiener klinische Wochenschrift·Julia RiedlWalther H Wernsdorfer
Apr 28, 2012·Acta Tropica·Florian AstelbauerJulia Walochnik
Jun 22, 2012·Journal of the Academy of Nutrition and Dietetics·Joseph I Boullata, Lauren M Hudson
Dec 29, 2009·Wiener klinische Wochenschrift·Maria GruberWalther H Wernsdorfer
May 26, 2011·Current Opinion in Pediatrics

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