PMID: 8602658Feb 1, 1996Paper

Pharmacodynamic interaction between propofol and alfentanil when given for induction of anesthesia

Anesthesiology
J VuykJ G Bovill

Abstract

Propofol and alfentanil often are combined during induction of anesthesia. However, the interaction between these agents during induction has not been studied in detail. The influence of alfentanil on the propofol concentration-effect relationships was studied for loss of eyelash reflex, loss of consciousness, and hemodynamic function in 20 unpremedicated ASA physical status 1 patients aged 20-55 yr. Patients were randomly divided into four groups to receive a computer- controlled infusion of alfentanil with target concentrations of 0, 50, 200, or 400 ng/ml (groups A, B, C, and D, respectively). While the target concentration of alfentanil was maintained constant, patients received a computer- controlled infusion of propofol, with an initial target concentration of 0.5-1 microgram/ml, that was increased every 12 min by 0.5-1 microgram/ml. Every 3 min, the eyelash reflex and state of consciousness were tested an an arterial blood sample was taken for blood propofol and plasma alfentanil determination. The propofol-alfentanil concentration-response relationships for loss of eyelash reflex and loss of consciousness were determined by nonlinear regression, and for the percentage of change in systolic blood pressure and heart rate b...Continue Reading

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Citations

Oct 20, 1999·Journal of Clinical Anesthesia·S SchraagM Georgieff
Oct 8, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Gregory A HollmanDevon K Christenson
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Jul 18, 2008·Anesthesia and Analgesia·Jan F A HendrickxSteven L Shafer
May 15, 2009·Anesthesia and Analgesia·Nicolas MongardonJean Guglielminotti
Jun 26, 2004·Clinical Pharmacokinetics·Bart-Jan LichtenbeltJaap Vuyk
Jun 10, 2009·Current Opinion in Anaesthesiology·Julia MetznerKaren B Domino
Sep 10, 2002·Anesthesiology·Benoît PlaudFrançois Donati
Apr 17, 2004·Anesthesiology·Martijn J MertensJaap Vuyk
Jan 27, 2006·Anesthesiology·Sanjay M BhanankerKaren B Domino
Jun 7, 2003·European Journal of Anaesthesiology·H SchwildenJ Schüttler
Oct 31, 2015·Anesthesia and Analgesia·Michel M R F StruysThomas W Schnider
Aug 2, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Miika KoskinenTapio Seppänen
Sep 1, 2015·Anesthesiology Clinics·Shamsuddin Akhtar, Ramachandran Ramani
Nov 5, 1999·European Journal of Anaesthesiology·H SinghA Matsuki
Aug 31, 2002·European Journal of Anaesthesiology·D H ConwayM E Simpson
Sep 12, 2013·Korean journal of anesthesiology·Yushi U AdachiKazuhiko Watanabe
Nov 29, 2011·The Journal of International Medical Research·Y J WonS Y Lee
Jun 18, 2002·British Journal of Anaesthesia·M P Dockery, G B Drummond
May 9, 2018·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Kwan Young LeeDong Kwan Kim
Jul 16, 2003·Acta Anaesthesiologica Scandinavica·P Y LequeuxL Barvais

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