Pharmacodynamic material basis of traditional Chinese medicine based on biomacromolecules: a review

Plant Methods
Wen-Jin ZhangLan-Ping Guo

Abstract

Biomacromolecules, the first components of bioactive substances in traditional Chinese medicines (TCM) have wide bioactivity-related efficacy but have not yet been fully appreciated compared to small molecule components. The present review brings a novel and systemic point of view to deepen the understanding of the pharmacodynamic material basis of TCM based on biomacromolecules (polysaccharides, proteins and nucleic acids). Biomacromolecules have been, are and will have considerable roles in the efficacy of Chinese medicine, as evidenced by the number of biological activities related to traditional clinical efficacy. The direct and indirect mechanisms of biomacromolecules are further accounted for in a variety of neurotransmitters, hormones, and immune substances to maintain immune function in both sensitive and stable equilibrium. The biological functions of biomacromolecules have been elaborated on in regard to their roles in the process of plant growth and development to the relationship between primary metabolism and secondary metabolism and to the indispensable role of polysaccharides, proteins, and nucleic acids in the quality formation of TCM. Understanding the functional properties and mechanisms of biological macromol...Continue Reading

References

Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M S McGrathJ Marsh
Jan 1, 1988·Annual Review of Biochemistry·T W RademacherR A Dwek
Feb 1, 1994·Antimicrobial Agents and Chemotherapy·J O KahnR Williams
Apr 1, 1994·Thrombosis Research·F Markwardt
Jul 18, 2002·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S P LiK W K Tsim
Feb 21, 2003·Biochemical and Biophysical Research Communications·Jian-Hua WangYong-Tang Zheng
Apr 5, 2005·Toxicon : Official Journal of the International Society on Toxinology·Pang-Chui ShawKam-Bo Wong
Mar 24, 2006·Immunology Letters·M Y K LeungK P Fung
May 24, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S P LiK W K Tsim
Jul 15, 2006·Molecular Plant-microbe Interactions : MPMI·Angela Garcia-BruggerAlain Pugin
Jan 13, 2009·Proteins·Liang HuangCong-Zhao Zhou
Jan 27, 2009·Phytotherapy Research : PTR·Zhisong ChenSoh Ha Chan
Nov 26, 2009·The American Journal of Chinese Medicine·Xing-Tai LiHui-Ying Chen
Dec 17, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Rong ShengYue Dai
Mar 17, 2010·Immune Network·Hee Sam NaHyun-Chul Lee
Nov 10, 2010·Expert Opinion on Therapeutic Targets·Ming-Hua JiangJian-Guo Jiang
Feb 22, 2011·Journal of Ethnopharmacology·Kai-Ping WangYu Zhang
Sep 23, 2011·Cellular Immunology·Lu-Hang ZhaoDeng-Po Weng
Oct 11, 2011·International Journal of Biological Macromolecules·Wei TanXiao-shan Zhao
Dec 3, 2011·International Journal of Biological Macromolecules·Yong ChenShujuan Liang
Dec 23, 2011·Inflammopharmacology·Wai-Man TangShun-Wan Chan
Feb 10, 2012·Journal of Natural Products·David J Newman, Gordon M Cragg
Apr 12, 2012·Nature Reviews. Microbiology·Nicole M KoropatkinEric C Martens
Sep 14, 2012·Nature·Valentina Tremaroli, Fredrik Bäckhed
Dec 19, 2012·International Journal of Biological Macromolecules·Tong LiuBaogang Liu
Apr 20, 2013·Respiratory Physiology & Neurobiology·Gabriela NosalovaBimalendu Ray
Aug 14, 2013·Journal of the Science of Food and Agriculture·Zuo-qi XiaoJia-chun Chen
Jul 30, 2014·Chinese Medicine·Kam Lok WongStephen Cho Wing Sze
Sep 23, 2014·International Journal of Biological Macromolecules·Chang-Won ChoHee-Do Hong

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Citations

Sep 16, 2020·Protein & Cell·Tzu-Lung LinHsin-Chih Lai
Mar 7, 2021·Marine Drugs·Qi-Ting ZhangYu-Fen Zhao
Jun 11, 2021·Carbohydrate Research·Cheng-Yang FuWei Cao
Jun 20, 2021·Drug Development Research·Huanhuan ZhuMinying Wang
Aug 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Akurange Sujeevi Dammadinna WickramasingheAnoja Priyadarshani Attanayake

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Methods Mentioned

BETA
pharmacotherapy
MDA

Software Mentioned

PAOF

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