Pharmacodynamic monitoring during acute intervention in ischaemic heart disease using a new echo-Doppler device

British Journal of Clinical Pharmacology
B SilkeS H Taylor

Abstract

1. We have utilised a new non-imaging echo-Doppler cardiac output device, using the principle of attenuated compensated volume flow (ACVF), to assess the cardiovascular effects of atenolol and buccal nitroglycerin (NTG) in a placebo-controlled study of 30 patients with coronary disease. 2. Atenolol (4 mg i.v.) reduced heart rate, cardiac output and time-averaged mean aortic velocity (P less than 0.01) and increased systemic vascular resistance (P less than 0.01). 3. Buccal NTG (5 mg) reduced systemic mean arterial pressure (P less than 0.01), cardiac stroke volume (P less than 0.05) and stroke length (P less than 0.01). 4. Thus although both drugs reduced time-averaged aortic velocity (an index of cardiac performance), the concomitant reduction in cardiac stroke length and tachycardia suggested sub-optimal cardiac filling for buccal NTG, whereas for atenolol (with the associated increased systemic vascular resistance but unchanged stroke length) attenuation of sympathetic stimulation at cardiac beta-adrenoceptors. 5. The ACVF method of cardiovascular monitoring should prove useful in human pharmacodynamic studies.

References

May 21, 1979·European Journal of Clinical Pharmacology·T L SvendsenJ Trap-Jensen
Jan 1, 1979·Ultrasonic Imaging·C F Hottinger, J D Meindl
Jan 1, 1975·Circulation·J H McAnultyS H Rahimtoola
Mar 1, 1975·Circulation·D O WilliamsD T Mason
Jan 1, 1988·British Journal of Anaesthesia·S H Taylor, B Silke
Jan 1, 1968·The American Journal of Cardiology·J O ParkerS Di Giorgi
Jul 1, 1981·Journal of Cardiovascular Pharmacology·B SilkeS H Taylor
Jan 1, 1984·British Heart Journal·H IhlenE Myhre
Jan 1, 1981·European Journal of Clinical Pharmacology·W G HendryS H Taylor
Jul 1, 1965·British Heart Journal·B CHRISTENSSONH WESTLING

❮ Previous
Next ❯

Citations

May 1, 1993·British Journal of Clinical Pharmacology·H HinrichsenW Kirch
May 1, 1995·British Journal of Clinical Pharmacology·M SiepmannW Kirch
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H Osuga, A M Hakim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.