Pharmacodynamic properties of HMR 3647, a novel ketolide, on respiratory pathogens, enterococci and Bacteroides fragilis demonstrated by studies of time-kill kinetics and postantibiotic effect

The Journal of Antimicrobial Chemotherapy
F J BoswellR Wise

Abstract

The pharmacodynamic properties of a novel ketolide (a new class of macrolide), HMR 3647, were investigated by studying time-kill kinetics and postantibiotic effect (PAE). The time-kill kinetics were studied at two inocula against three strains each of Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecalis, Enterococcus faecium and Bacteroides fragilis. The PAEs of HMR 3647 were also investigated on these organisms at concentrations equivalent to 1, 4 and 10 x MIC. The time-kill kinetic data demonstrated that HMR 3647 is predominantly bacteriostatic and only slowly bactericidal at higher concentrations. HMR 3647 exhibited a significant PAE with all strains studied, ranging from 1.2 h to 8.2 h at 10 x MIC. The bacteriostatic activity and significant PAE demonstrated by HMR 3647 are similar to those previously obtained with other macrolides.

Citations

Nov 15, 2002·International Journal of Antimicrobial Agents·Melinda M NeuhauserSusan L Pendland
Oct 6, 1999·Current Opinion in Microbiology·D T Chu
Sep 27, 2002·Current Opinion in Pharmacology·Angela M Nilius, Zhenkun Ma
Dec 20, 2000·Antimicrobial Agents and Chemotherapy·I OdenholtO Cars
May 17, 2001·Antimicrobial Agents and Chemotherapy·A BonnefoyA M Girard
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Darren AbbanatKaren Bush
Oct 17, 2001·Pharmacotherapy·D T BeardenK W Garey
Aug 1, 2002·Drugs·George G ZhanelDaryl J Hoban
Jun 18, 2004·Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia·E Calbo, J Garau
Feb 15, 2001·Expert Opinion on Investigational Drugs·H M Yassin, L L Dever
Jun 9, 1999·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·T NichterleinH Hof
Nov 29, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L DragoM R Gismondo
Oct 4, 2005·Clinical Therapeutics·Megan Nguyen, Eunice P Chung
Jan 9, 2004·Infectious Disease Clinics of North America·Dana MaglioCharles H Nightingale
Feb 28, 2002·Expert Opinion on Pharmacotherapy·George G Zhanel, Daryl J Hoban
Apr 4, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A Bryskier
Apr 12, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases· Pascual AE J Perea
Oct 17, 2007·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Toshi Akashi
Oct 16, 2004·Expert Review of Anti-infective Therapy·Karen M Spiers, Marcus J Zervos
Jul 20, 2004·Drugs·Keri Wellington, Stuart Noble
Apr 27, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Nishaminy Kasbekar, Pinak S Acharya
Dec 13, 2017·Proceedings of the National Academy of Sciences of the United States of America·Maxim S SvetlovAlexander S Mankin
Apr 2, 1999·Antimicrobial Agents and Chemotherapy·K MalathumB E Murray
Mar 4, 2000·Journal of Pharmaceutical and Biomedical Analysis·B Lingerfelt, W S Champney
Feb 27, 1999·Antimicrobial Agents and Chemotherapy·K E PiperR Patel

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