PMID: 2297100Jan 1, 1990Paper

Pharmacodynamics and pharmacokinetics of epidural ropivacaine in humans

Anesthesia and Analgesia
J A KatzD D Denson


The purpose of this study was to characterize the pharmacodynamics and pharmacokinetics of three concentrations of the new long-acting amide local anesthetic, ropivacaine, given epidurally in 15 physical status ASA I or II patients for elective lower-extremity orthopedic procedures using a nonrandomized open-label design. Three groups of five patients each received either 0.5%, 0.75%, or 1.0% ropivacaine. Upper and lower levels of analgesia to pinprick were determined at frequent intervals until normal sensation had completely returned. Motor blockade was assessed by use of a modified Bromage scale after each determination of level of analgesia. Fifteen venous blood samples were collected over 12 h after ropivacaine injection. Pharmacokinetic parameters were derived using serum concentration-time data. No significant differences were found between the three groups in terms of onset or recovery of motor and sensory blockade. Median maximum thoracic levels of analgesia achieved were 8, 6, and 5 for the 0.5%, 0.75%, and 1.0% groups, respectively, and occurred at 29 +/- 11, 37 +/- 21, and 30 +/- 9 min. Respective times to two-segment regression were 2.8 +/- 1.0, 3.0 +/- 0.5, and 2.9 +/- 0.6 h. Total durations of sensory blockade we...Continue Reading


Apr 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N H Badner, W E Komar
May 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N H BadnerW E Komar
Feb 18, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·E CrosbyR Shukla
Apr 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S St-OngeM Girard
Jun 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H A MuirA Macarthur
Mar 24, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P RautomaO Erkola
Nov 17, 2010·European Journal of Clinical Pharmacology·Maria CusatoMario Regazzi
Feb 9, 2000·Pharmacology & Therapeutics·N J O'Keeffe, T E Healy
Jul 1, 1997·International Journal of Obstetric Anesthesia·T I Ala-KokkoK Vähäkangas
Mar 29, 2000·Paediatric Anaesthesia·W HabreC Sims
May 1, 1991·Anaesthesia·F Reynolds
Jan 1, 1995·Acta Anaesthesiologica Scandinavica·C J ErichsenH Kehlet
Jan 1, 2010·Anesthesia, Essays and Researches·Sukhminder Jit Singh BajwaAparajita Panda
Dec 5, 2000·British Journal of Anaesthesia·T G HansenR Bergesio
Nov 7, 2000·British Journal of Anaesthesia·P A LönnqvistM Bielenstein
Oct 1, 1993·Biopharmaceutics & Drug Disposition·J A KatzP O Bridenbaugh
Jan 24, 2007·European Journal of Anaesthesiology·I CoskunerK Elcicek
Aug 31, 2004·Anesthesia and Analgesia·Sachiko TodorokiKoji Sumikawa
Sep 28, 2001·Anesthesia and Analgesia·M E McCannC B Berde

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