PMID: 9638074Jun 25, 1998Paper

Pharmacodynamics and pharmacokinetics of tolfenamic acid in ruminating calves: evaluation in models of acute inflammation

The Veterinary Journal
P LeesG Gettinby

Abstract

Injections of mild irritants intradermally (carrageenan, zymosan and dextran) and intracaveally (carrageenan) in a tissue cage model of inflammation were used in studies of the pharmacodynamics and pharmacokinetics of tolfenamic acid administered intramuscularly in calves. Inhibition of serum thromboxane (TX)B2 and inflammatory exudate prostaglandin (PG)E2 were used as indicators of the magnitude and time course of blockade of cyclo-oxygenase isoforms COX-1 and COX-2, respectively. Single doses of 2, 4 and 8 mgkg-1 tolfenamic acid partially inhibited irritant-induced rises in skin temperature (non-dose dependently) and skin oedema (dose-dependently). These doses also markedly inhibited serum TXB2 synthesis and the duration of inhibition was dose-related. A dose of 2 mgkg-1 tolfenamic acid also attenuated skin temperature rise over carrageenan-injected tissue cages, and markedly inhibited exudate PGE2 synthesis, even though drug penetration into both exudate and tissue cage transudate was limited. Tolfenamic acid pharmacokinetics were characterized by a relatively short tmax (0.94-2.04 h), a high estimated Vdarea (1.79-3.20 Lkg-1), an estimated t1/2 beta of 8.01-13.50 h and Cl beta of 0.142-0.175 Lkg-1h-1. The actions of tolfena...Continue Reading

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Citations

Jan 1, 2003·Research in Veterinary Science·P SidhuP Lees
Mar 6, 2003·The Veterinary Journal·P LeesC Waters
Jul 15, 2000·American Journal of Veterinary Research·P Kay-MugfordP Conlon
Nov 14, 2012·Journal of Veterinary Pharmacology and Therapeutics·V Dinakaran, V K Dumka
Jun 19, 2010·Journal of Veterinary Pharmacology and Therapeutics·M Martinez, S Modric
Dec 17, 2004·Journal of Veterinary Pharmacology and Therapeutics·P LeesP L Toutain
Feb 22, 2005·Journal of Veterinary Pharmacology and Therapeutics·P K SidhuP Lees
Mar 14, 2007·Journal of Veterinary Pharmacology and Therapeutics·G S RaoN C Shankaramurthy
Aug 28, 2009·The Veterinary Journal·Georgios A DelisGeorgios C Batzias
Mar 31, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Manoj ShuklaJ K Malik
Aug 8, 2018·Journal of Veterinary Pharmacology and Therapeutics·Orhan CorumKamil Uney
Aug 4, 2020·Journal of Veterinary Pharmacology and Therapeutics·Ibrahim Ozan TekeliKamil Uney
Nov 11, 2019·Journal of Veterinary Pharmacology and Therapeutics·Natsuda RaweewanSaranya Poapolathep
Jun 12, 2020·Journal of Veterinary Pharmacology and Therapeutics·Natsuda RaweewanSaranya Poapolathep
Apr 3, 2019·Animal : an International Journal of Animal Bioscience·L InglisA Thompson
Feb 10, 2021·Journal of Veterinary Pharmacology and Therapeutics·Erdinc TurkKamil Uney
Feb 19, 2021·Journal of Veterinary Pharmacology and Therapeutics·Erdinc TurkKamil Uney

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