Pharmacoeconomic impact of different regimens to prevent cytomegalovirus infection in renal transplant recipients

Kidney & Blood Pressure Research
Lukas KielbergerTomas Reischig

Abstract

The aim of this study was to determine the cost impact of four different strategies for prevention of cytomegalovirus (CMV) disease after renal transplantation. Hospitalization data and medical resource utilization data were prospectively collected alongside two randomized trials. In the first trial, the patients were randomized to 3-month prophylaxis with either oral ganciclovir (1 g t.i.d., n = 36) or valacyclovir (2 g q.i.d., n = 35), and to the control group (n = 12) managed by deferred therapy. In the second trial, the patients were randomly assigned to 3-month valacyclovir prophylaxis (n = 34) or preemptive therapy with valganciclovir (900 mg b.i.d. for a minimum of 14 days, n = 36) for significant CMV DNAemia. The cost analysis involved all real costs directly related to CMV during the first year after renal transplantation. The mean CMV-associated costs per patient were EUR 4,581, 2,577, 4,968, and 8,050 in patients in the ganciclovir, valacyclovir, preemptive, and deferred therapy groups, respectively (p < 0.001). Valacyclovir prophylaxis was significantly less expensive than any other regimen. The cost of one episode of CMV disease was EUR 7,510 per patient. Due to excessive incidence of CMV disease, deferred therapy ...Continue Reading

References

Jun 1, 1993·Transplantation·J M McCarthyP A Keown
Sep 28, 2002·The Journal of Infectious Diseases·Jean-Paul Squifflet, Christophe Legendre
Oct 24, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Solbjørg SagedalHalvor Rollag
Apr 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Mark A SchnitzlerDaniel C Brennan
Mar 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Carlos PayaUNKNOWN Valganciclovir Solid Organ Transplant Study Group
Mar 15, 2005·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Christophe LegendreIsabelle Durand-Zaleski
Aug 18, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·I D PavlopoulouJ N Boletis
Mar 15, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Tomás ReischigVladislav Treska
Jun 20, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J A KhouryD C Brennan
Dec 12, 2007·Nano Letters·Robert R JohnsonMichael L Klein
Dec 21, 2007·The New England Journal of Medicine·Jay A Fishman
Mar 14, 2008·Transplantation·Gerhard OpelzUNKNOWN Collaborative Transplant Study Report
Sep 19, 2009·Journal of the American Society of Nephrology : JASN·Fu L LuanAkinlolu Ojo
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A HumarUNKNOWN AST Infectious Diseases Community of Practice
Mar 13, 2010·Transplantation·Camille N KottonUNKNOWN Transplantation Society International CMV Consensus Group
Apr 1, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A HumarP Peeters
Aug 11, 2010·Expert Review of Anti-infective Therapy·Tomás Reischig

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Citations

Jul 31, 2013·Transplantation·Camille N KottonUNKNOWN Transplantation Society International CMV Consensus Group
Sep 26, 2014·Expert Review of Pharmacoeconomics & Outcomes Research·Tomas Reischig, Martin Kacer
Mar 31, 2015·Transplant Infectious Disease : an Official Journal of the Transplantation Society·K W Matter-WalstraN J Mueller
Apr 1, 2015·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M KacerT Reischig
May 3, 2016·Transplantation Reviews·J Torre-CisnerosUNKNOWN Spanish Network for Research in Infectious Diseases (REIPI)
Jun 25, 2016·Expert Opinion on Pharmacotherapy·Luciano PotenaLaura Borgese
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yoichiro NatoriUNKNOWN CMV Consensus Forum
Nov 27, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Tomas ReischigMirko Bouda
Sep 29, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Narisa RuenroengbunAmmarin Thakkinstian
Nov 24, 2021·Future Microbiology·Kerusha GovenderRaveen Parboosing

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