PMID: 9161627May 15, 1997Paper

Pharmacoeconomic model of enoxaparin versus heparin for prevention of deep vein thrombosis after total hip replacement

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
D W HawkinsK P Krueger

Abstract

The costs of heparin and enoxaparin to prevent deep vein thrombosis (DVT) after total hip replacement in the U.S. treatment environment were compared. A decision model was used in a pharmacoeconomic comparison of subcutaneous enoxaparin and subcutaneous heparin, each given for seven days, for the prophylaxis of DVT. In the model, three outcome pathways could follow prophylaxis: proximal DVT, distal DVT, and no DVT (but with a possible false-positive clinical diagnosis of DVT). Probabilities of thromboembolic events and major bleeding were derived from three randomized clinical trials. Account was also taken of the effects of pulmonary embolism (PE). Pharmacoeconomic studies and expert opinion were relied on for the model's principal resource-use categories and costs for DVT prophylaxis, clinical diagnosis of DVT and PE, and DVT and PE treatment. The outcome of choice for the model was the number of DVT events avoided. Regardless of the trial data used, the total mean cost of enoxaparin prophylaxis ($3336 to $3380) exceeded the cost of heparin prophylaxis ($3292 to $3330). However, enoxaparin was more cost-effective in avoiding DVT than heparin, irrespective of the trial on which the analysis was modeled. A sensitivity analysis ...Continue Reading

Citations

Feb 15, 2000·Journal of General Internal Medicine·C A EstradaG R Heudebert
Jan 6, 2004·American Journal of Therapeutics·William J SpruillRyan B Leslie
May 21, 2004·Expert Review of Cardiovascular Therapy·Andreas Greinacher
Sep 25, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·William J SpruillRyan B Leslie
Apr 5, 2000·PharmacoEconomics·W E WadeM Perri
May 9, 2002·Expert Opinion on Pharmacotherapy·Alexander G G Turpie, Jacqueline A Mason
Aug 20, 2004·Pharmacotherapy·David Hawkins
Jan 17, 2007·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Jonas LundkvistBengt Jönsson
Sep 15, 2004·Archives of Orthopaedic and Trauma Surgery·Patrick HaentjensLieven Annemans
May 11, 2004·American Journal of Therapeutics·William E WadeRyan B Leslie
May 21, 2004·Expert Review of Cardiovascular Therapy·Thomas Hofmann
Sep 1, 2004·Pharmacotherapy·Paul P Dobesh, UNKNOWN Heparin Consensus Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.