PMID: 16509026Mar 3, 2006Paper

Pharmacoeconomic modeling of nesiritide versus dobutamine for decompensated heart failure

Pharmacotherapy
Tobias GerhardAbraham G Hartzema

Abstract

To model the cost-effectiveness of nesiritide compared with dobutamine in patients with decompensated heart failure. Cost-effectiveness analysis. A decision tree model was derived from randomized clinical trial data and data from a previously published economic study. Four cost-effectiveness analyses were performed: analysis 1 -- full probabilistic analysis, repeatedly sampled probabilities for 6-month mortality and hospital readmission from distributions based on 95% confidence intervals (CIs); analysis 2 -- best-case nesiritide analysis, used the limiting values of the 95% CI favorable to nesiritide; analysis 3 -- best-case dobutamine analysis, used the limiting values of the 95% CI favorable to dobutamine; and analysis 4 -- replicated the previously published cost-effectiveness study and served as a methodologic control. Fifty-one consecutive Monte Carlo simulations for cohorts of 1000 hypothetical patients were performed for each analysis. Incremental cost, incremental effectiveness, and incremental cost-effectiveness ratios (ICERs) were calculated for nesiritide versus dobutamine. Analysis 1 showed a mean ICER of 767 US dollars/life-year gained for nesiritide versus dobutamine (incremental cost 251 US dollars +/- 290 US do...Continue Reading

References

Mar 27, 2001·Journal of Cardiac Failure·W S Colucci
Dec 18, 2002·American Heart Journal·Andrew J BurgerUNKNOWN Prospective Randomized Evaluation of Cardiac Ectopy with Dobutamine or Natrecor Therapy
Dec 19, 2002·Drugs·Gillian M Keating, Karen L Goa
Aug 2, 2003·Lancet·James A de LemosMark H Drazner
Aug 19, 2003·Pharmacotherapy·Brian F McBride, C Michael White
Aug 19, 2003·Pharmacotherapy·John A NoviaskyWilliam Darko
Sep 12, 2003·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Daniel A LewisWendell S Akers
Sep 12, 2003·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·W Frank Peacock
Nov 5, 2003·Pharmacotherapy·Issam ZinehJulie A Johnson
Jan 31, 2004·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·James M HoffmanKarrie M Hontz
Apr 21, 2004·Current Opinion in Cardiology·Madan Sharma, John R Teerlink
Sep 21, 2004·Journal of Cardiovascular Pharmacology and Therapeutics·Richard ChangJ Thomas Heywood
Oct 27, 2004·Expert Review of Cardiovascular Therapy·John V Wylie, Lana Tsao
Nov 20, 2004·Current Problems in Cardiology·Vijaya K MunagalaMargaret M Redfield
Mar 23, 2005·Circulation·Jonathan D Sackner-BernsteinKeith D Aaronson
Mar 30, 2005·Circulation·John R Teerlink, Barry M Massie
Apr 21, 2005·JAMA : the Journal of the American Medical Association·Jonathan D Sackner-BernsteinKeith Aaronson
Jul 15, 2005·The New England Journal of Medicine·Eric J Topol

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