PMID: 7371707Feb 1, 1980Paper

Pharmacogenetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine

European Journal of Clinical Pharmacology
L BertilssonH U Schulz

Abstract

Two subjects from each of the three groups of homozygous rapid, heterozygous, and homozygous non-metabolizers (N-oxidation) of sparteine received a single oral dose of debrisoquine. The urinary ratio of debrisoquine/4-hydroxy-debrisoquine, reflecting the individual's capacity to C-hydroxylate debrisoquine, was closely related to his phenotype for sparteine metabolism. This indicates that the two metabolic reactions are controlled by similar if not identical genetic factors.

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Sep 1, 1994·Journal of Clinical Pharmacology·D G May
Jan 1, 1984·European Journal of Clinical Pharmacology·A Küpfer, R Preisig
Jan 1, 1983·European Journal of Clinical Pharmacology·M SandozR Volmat
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Jan 11, 2001·Archives of Pathology & Laboratory Medicine·W Kalow

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