Pharmacogenetic Profile and the Occurrence of Visual Hallucinations in Patients With Sporadic Parkinson's Disease

Journal of Clinical Pharmacology
Erinaldo Ubirajara Damasceno Dos SantosPaulo Roberto Eleutério de Souza

Abstract

Visual hallucinations are significant nonmotor symptoms in the course of treatment of Parkinson's disease. Previous studies have shown that the interindividual variability and pharmacogenetic profile of Parkinson's disease patients seem to influence the occurrence of visual hallucinations. In our study, we investigated a possible relationship of sequence variants in DRD1, DRD2, DRD3, DAT1, and COMT genes with the presence of visual hallucinations in Parkinson's disease patients. A total of 224 Brazilian patients from the Pro-Parkinson service at the Clinical Hospital of the University of Pernambuco, diagnosed with sporadic Parkinson's disease, were enrolled. Parkinson's disease patients were divided into 2 groups based on the presence or absence of visual hallucinations. The sequence variants for DRD1, DRD2, DRD3, DAT1, and COMT were determined through the polymerase chain reaction-restriction fragment length polymorphism technique. Multiple Poisson regression analyses showed that individuals carrying the DRD3 Ser/Ser and Ser/Gly genotypes presented increased prevalence ratios of visual hallucinations (9.7-fold and 4.4-fold, respectively; P < .001). Regarding DAT1 rs28363170, there was a 9.82-fold increase in the prevalence rat...Continue Reading

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Citations

Nov 7, 2019·Mini Reviews in Medicinal Chemistry·Bianca L B MarinoLorane I S Hage-Melim
Jul 14, 2020·The International Journal of Neuropsychopharmacology·Nadia S Hejazi
Sep 8, 2020·Pharmacogenomics·Sara Redenšek, Vita Dolžan
Aug 4, 2020·Journal of Parkinson's Disease·Joseph Savitt, Rachid Aouchiche
May 24, 2019·Neuromolecular Medicine·Erinaldo Ubirajara Damasceno Dos SantosPaulo Roberto Eleutério de Souza
Nov 6, 2020·Molecular Biology Reports·Erinaldo Ubirajara Damasceno Dos SantosPaulo Roberto Eleutério de Souza
May 1, 2021·International Journal of Molecular Sciences·Luca MagistrelliFranca Marino
Jun 10, 2021·Medicinal Research Reviews·Ramón CacabelosJuan C Carril

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