journal cover

Pharmacogenetic screening of the gene deletion and duplications of CYP2D6

Drug Metabolism Reviews

Mar 17, 2007

Irma MeijermanJan H M Schellens

Abstract

Cytochrome P450 (CYP) 2D6 is one of the most important enzymes involved in the metabolism of drugs. Multiple, clinically relevant, genetic variants of this gene have been identified and, among them, a gene deletion as well as multiplications of the gene. These large structural mutations...read more

Mentioned in this Paper

Gene Deletion Abnormality
Metabolic Process, Cellular
Real-Time Polymerase Chain Reaction
Nested Polymerase Chain Reaction
Metabolism
Metabolic Aspects
Pharmacogenetics
Pseudogenes
Cyp2d6 Gene Analysis
Enzymes, hematological
Paper Details
References
  • References48
  • Citations15
12345
  • References48
  • Citations15
12

Similar Papers Found In These Feeds

Chromosomal Duplication

Chromosomal duplication is a result of extra genetic material within the area of the chromosome. The duplication may have no effect or may be expressed in the phenotype of that individual. Some duplications are thought to be of evolutionary selection. Discover the latest research on chromosomal duplication here.

Pharmacogenetics & Pharmacogenomics

Pharmacogenetics and pharmacogenomics (pgx) are rapidly growing fields that aim to elucidate the genetic basis for the interindividual differences in drug response. Here is the latest research on pharmacogenetics and pharmacogenomics.

Mechanisms of CYP450

Cytochrome P450 (CYP450) are a family of enzymes involved in two major processes, such as the synthesis of fatty acids, steroids, and biles acids, and the metabolism of toxins and drugs. Discover the latest research on the Mechanisms of CYP450 enzymes here.

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

© 2020 Meta ULC. All rights reserved

Pharmacogenetic screening of the gene deletion and duplications of CYP2D6

Drug Metabolism Reviews

Mar 17, 2007

Irma MeijermanJan H M Schellens

PMID: 17364880

DOI: 10.1080/03602530600952206

Abstract

Cytochrome P450 (CYP) 2D6 is one of the most important enzymes involved in the metabolism of drugs. Multiple, clinically relevant, genetic variants of this gene have been identified and, among them, a gene deletion as well as multiplications of the gene. These large structural mutations...read more

Mentioned in this Paper

Gene Deletion Abnormality
Metabolic Process, Cellular
Real-Time Polymerase Chain Reaction
Nested Polymerase Chain Reaction
Metabolism
Metabolic Aspects
Pharmacogenetics
Pseudogenes
Cyp2d6 Gene Analysis
Enzymes, hematological

Related Papers

Paper Details
References
  • References48
  • Citations15
12345
  • References48
  • Citations15
12
/papers/pharmacogenetic-screening-of-the-gene-deletion/17364880