Pharmacogenetics - five decades of therapeutic lessons from genetic diversity

Nature Reviews. Genetics
Urs A Meyer

Abstract

Physicians have long been aware of the subtle differences in the responses of patients to medication. The recognition that a part of this variation is inherited, and therefore predictable, created the field of pharmacogenetics fifty years ago. Knowing the gene variants that cause differences among patients has the potential to allow 'personalized' drug therapy and to avoid therapeutic failure and serious side effects.

References

Sep 17, 1977·Lancet·A MahgoubR L Smith
Sep 1, 1979·European Journal of Clinical Pharmacology·M EichelbaumH J Dengler
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M BlumU A Meyer
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K P VatsisW W Weber
Jan 1, 1989·Journal of Inherited Metabolic Disease·C R Scriver
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R C SkodaU A Meyer
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·U M ZangerU A Meyer
Jan 1, 1984·European Journal of Clinical Pharmacology·A Küpfer, R Preisig
May 1, 1982·British Journal of Clinical Pharmacology·G C KahnD S Davies
Feb 1, 1995·Pharmacogenetics·K P VatsisM V Relling
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·I JohanssonM Ingelman-Sundberg
Aug 1, 1996·Pharmacogenetics·T H Sullivan-KloseJ A Goldstein
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·U A Meyer, U M Zanger
Nov 23, 2000·Lancet·U A Meyer
Jul 18, 2002·Nature Reviews. Drug Discovery·Dan M Roden, Alfred L George
Feb 7, 2003·The New England Journal of Medicine·Richard Weinshilboum
Feb 7, 2003·The New England Journal of Medicine·William E Evans, Howard L McLeod
Jun 24, 2003·Drug Discovery Today·Edward M SellersLeona C Fernandes
Jul 21, 1956·Lancet·H LEHMANN, E RYAN
Sep 14, 1956·Science·A S ALVINGC E ICKES
Oct 19, 1957·Journal of the American Medical Association·A G MOTULSKY
Dec 1, 1957·Canadian Journal of Biochemistry and Physiology·W KALOW, N STARON
Aug 13, 1960·British Medical Journal·D A EVANSV A McKUSICK
Nov 18, 2003·Naunyn-Schmiedeberg's Archives of Pharmacology·Ulrich M ZangerMichel Eichelbaum
Nov 25, 2003·Nature Reviews. Genetics·David B GoldsteinSanjay M Sisodiya
Dec 6, 2003·Pharmacological Reviews·Christoph Handschin, Urs A Meyer
Dec 16, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Daniel W NebertElliot S Vesell
Aug 23, 1952·Journal of the American Medical Association·C B CLAYMANA S ALVING
Jan 1, 1932·Proceedings of the National Academy of Sciences of the United States of America·A L Fox

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Citations

Dec 15, 2007·Molecular Diagnosis & Therapy·Ramón Cacabelos
May 2, 2006·Molecular Diagnosis & Therapy·Elena García-MartínJosé A G Agúndez
Aug 13, 2008·Analytical and Bioanalytical Chemistry·Ulrich M ZangerMatthias Schwab
Jan 13, 2006·European Journal of Clinical Pharmacology·Hai-Ling QiaoYu-Zhong Guo
Apr 12, 2008·European Archives of Psychiatry and Clinical Neuroscience·Ramón Cacabelos
Oct 14, 2009·Human Genetics·Cristina Rodriguez-AntonaMagnus Ingelman-Sundberg
Jul 26, 2005·Journal of Human Genetics·Barkur S Shastry
Jun 14, 2006·Journal of Chemical Ecology·Jennifer S SorensenM Denise Dearing
Nov 5, 2010·International Journal of Clinical Pharmacy·Bob WilffertUNKNOWN KNMP working group Pharmacogenetics
Mar 3, 2011·International Journal of Clinical Pharmacy·Bob WilffertUNKNOWN KNMP working group Pharmacogenetics
Nov 17, 2010·Current Oncology Reports·Terri S Armstrong, Mark R Gilbert
Dec 6, 2011·Archives of Pharmacal Research·Hee-Doo Yoo, Yong-Bok Lee
Jan 22, 2009·The Pharmacogenomics Journal·F PassettiF F Costa
Oct 12, 2011·The Pharmacogenomics Journal·S M TseS T Weiss
Jan 4, 2012·The Pharmacogenomics Journal·B AlmogueraUNKNOWN Spanish Consortium of Pharmacogenetics Research in Schizophrenia
Jul 5, 2012·The Pharmacogenomics Journal·A SavonarolaF Silvestris
Jul 7, 2011·Genetic Testing and Molecular Biomarkers·Laura N RiccardiSusi Pelotti
Jun 21, 2011·Omics : a Journal of Integrative Biology·Fabio BagnoliRino Rappuoli
Jul 30, 2009·European Heart Journal·Céline VerstuyftRichard B Kim
Aug 22, 2012·Human Molecular Genetics·Chun-Yu WeiYuan-Tsong Chen
Mar 11, 2005·Current Opinion in Obstetrics & Gynecology·Tze Kin Lau, Tse Ngong Leung
May 19, 2005·Pharmacogenetics and Genomics·Allan B OkeyPatricia A Harper
Jun 11, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Valeriya Lyssenko
Mar 12, 2009·Current Opinion in Lipidology·Valeriya Lyssenko, Leif Groop
Aug 13, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Magnus Ingelman-Sundberg, Cristina Rodriguez-Antona
Mar 20, 2010·Genome Medicine·Jean-Sébastien Hulot
May 20, 2009·Pharmacogenomics·Gregory A PolandRobert M Jacobson
May 31, 2011·Pharmacogenomics·Richard M Watanabe
Dec 17, 2009·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Sue K Park, Ji-Yeob Choi
Nov 5, 2009·Clinical Medicine : Journal of the Royal College of Physicians of London·Munir Pirmohamed
Apr 14, 2006·Pharmacogenomics·Robert L Davis, Muin J Khoury
Jul 15, 2005·Pharmacogenomics·Christodoulos S Flordellis
Nov 13, 2012·Annual Review of Pharmacology and Toxicology·Urs A MeyerMatthias Schwab
Jun 6, 2014·Annual Review of Genomics and Human Genetics·Munir Pirmohamed
Oct 25, 2013·International Review of Psychiatry·Andrea Gaedigk

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