Pharmacogenetics and anaesthetic drugs: Implications for perioperative practice

Annals of Medicine and Surgery
Arash Behrooz

Abstract

Pharmacogenetics seeks to elucidate the variations in individual's genetic sequences in order to better understand the differences seen in pharmacokinetics, drug metabolism, and efficacy between patients. This area of research is rapidly accelerating, aided by the use of novel and more economical molecular technologies. A substantial evidence base is being generated with the hopes that in the future it may be used to generate personalised treatment regimens in order to improve patient comfort and safety and reduce incidences of morbidity and mortality. Anaesthetics is an area of particular interest in this field, with previous research leading to better informed practice, specifically with regards to pseudocholinesterase deficiency and malignant hyperthermia. In this review, recent pharmacogenetic data pertaining to anaesthetic drugs will be presented and possible future applications and implications for practice will be discussed.

References

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Citations

Mar 16, 2016·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Tai-Ming KoYuan-Tsong Chen
Aug 19, 2017·Journal of Lipid Research·Benjamin Michael DavisM Francesca Cordeiro
Jul 12, 2018·Advances in Therapy·Riccardo CompagnoniPietro Randelli
Jan 10, 2018·Anaesthesia·K Patton, D C Borshoff
Mar 12, 2019·Journal of Neural Engineering·Yuxiao YangMaryam M Shanechi
Nov 7, 2019·Personalized Medicine·Lidija Bach-RojeckyDragan Primorac
Jul 28, 2020·Journal of Personalized Medicine·Sara ZareiHooman Mirzakhani
Dec 20, 2018·Frontiers in Pharmacology·Shuqin ZhouR Stephanie Huang
Jun 27, 2019·Journal of Neurophysiology·Fahad IqbalNaweed I Syed

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Methods Mentioned

BETA
biopsy
genotyping

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