Pharmacogenetics and analgesic effects of antidepressants in chronic pain management

Personalized Medicine
Frédérique RodieuxMarie Besson

Abstract

Antidepressants are widely administered to chronic pain patients, but there is large interindividual variability in their efficacy and adverse effect rates that may be attributed to genetic factors. Studies have attempted to determine the impact of genetic polymorphisms in enzymes and transporters that are involved in antidepressant pharmacokinetics, for example, cytochrome P450 and P-gp. The impacts of genetic polymorphisms in the targets of antidepressants, such as the serotonin receptor or transporter, the noradrenaline transporter and the COMT and monoamine oxydase enzymes, have also been described. This manuscript discusses the current knowledge of the influence of genetic factors on the plasma concentrations, efficacy and adverse effects of the major antidepressants used in pain management.

References

Jun 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·S Tyrer
Nov 1, 1992·Clinical Pharmacology and Therapeutics·S H SindrupL F Gram
May 7, 1992·The New England Journal of Medicine·M B MaxR Dubner
Apr 1, 1990·Clinical Pharmacology and Therapeutics·S H SindrupH Beck-Nielsen
Oct 1, 1987·Human Genetics·D F CallenI B Roninson
Jun 27, 1983·Life Sciences·F RigalJ C Pechadre
Jan 9, 1999·Medical Hypotheses·J S Markowitz, K S Patrick
Jan 16, 1999·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G SmithC R Wolf
May 20, 1999·Annual Review of Pharmacology and Toxicology·S V AmbudkarM M Gottesman
Oct 16, 1999·Lancet·A M ElliottW A Chambers
Mar 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·S HoffmeyerU Brinkmann
Aug 19, 2000·Annals of Medicine·D Fishbain
Oct 2, 2001·Journal of Psychiatric Research·C CusinE Smeraldi
Feb 20, 2002·British Journal of Clinical Pharmacology·Leif BertilssonAyman Al-Shurbaji
Jun 12, 2002·The International Journal of Neuropsychopharmacology·Cristina CusinEnrico Smeraldi
Jul 11, 2002·Psychopharmacology·Susan StaddonRobert W Kerwin
Nov 20, 2002·Pharmacogenetics·Caryn LermanLeonard Epstein
Jan 22, 2003·Advanced Drug Delivery Reviews·Alfred H Schinkel, Johan W Jonker
Mar 26, 2003·Journal of Psychiatric Research·Manfred Uhr, Markus T Grauer
Sep 30, 2003·Pharmacogenetics·Julia KirchheinerJürgen Brockmöller
Nov 18, 2003·Naunyn-Schmiedeberg's Archives of Pharmacology·Ulrich M ZangerMichel Eichelbaum
Dec 4, 2003·European Journal of Clinical Investigation·I Cascorbi

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