Pharmacogenetics in pediatrics. Implications for practice
Cumulative experience with pharmacotherapy in children indicates that it is difficult to prescribe medications rationally solely on the basis of patient age. Furthermore, the apparent drug biotransformation phenotype may be influenced by disease (e.g., infection), environmental factors (e.g., diet and environmental contaminants), and concurrent medications. Therefore, characterization of drug biotransformation pathways during development and, at a given developmental stage, the effects of known modulators of drug biotransformation are essential for optimum treatment. This is particularly true when one considers that altered drug biotransformation may contribute significantly to therapeutic failure (e.g., graft rejection with inadequate serum and tissue concentrations of cyclosporin and myelotoxicity consequent to a relative inability to metabolize normal doses of certain antineoplastic agents). Accordingly, the goals of coordinated clinical and basic investigations should be to characterize important drug biotransformation pathways for compounds under development and intended for use in pediatrics and to identify the population extremes or "outliers" to aid in selection of an appropriate dosage range for efficacy studies. Acqui...Continue Reading
Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites
Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes
Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics
Differential foetal development of the O- and N-demethylation of codeine and dextromethorphan in man
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Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion
Purification of a human liver cytochrome P-450 immunochemically related to several cytochromes P-450 purified from untreated rats
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The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature
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A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase
Caffeine as a probe for CYP1A2 activity: potential influence of renal factors on urinary phenotypic trait measurements
Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylation
Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism
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Higher activity of polymorphic thiopurine S-methyltransferase in erythrocytes from neonates compared to adults
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Evidence that poor metabolizers of (S)-mephenytoin could be identified by haplotypes of CYP2C19 in Japanese
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Consensus conference on the evaluation of drugs to treat children with inflammatory bowel disease. Philadelphia, Pennsylvania, USA. October 18-19, 1997
Hemoglobin adducts of the human bladder carcinogen o-toluidine after treatment with the local anesthetic prilocaine
Functionally gene-linked polymorphic regions and genetically controlled neurotransmitters metabolism
Inhaled budesonide induced Cushing's syndrome in cystic fibrosis patients, due to drug inhibition of cytochrome P450
Maximizing the value of medicines by including pharmacogenetic research in drug development and surveillance
Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis
The role of cisapride in the treatment of pediatric gastroesophageal reflux. The European Society of Paediatric Gastroenterology, Hepatology and Nutrition
Coadministration of mefloquine and chloroqine: use of a pharmacokinetic-based approach to reduce toxicity
Important role of prodromal viral infections responsible for inhibition of xenobiotic metabolizing enzymes in the pathomechanism of idiopathic Reye's syndrome, Stevens-Johnson syndrome, autoimmune hepatitis, and hepatotoxicity of the therapeutic doses of acetaminophen used in genetically predisposed persons
Pediatric rheumatology for the adult rheumatologist I: therapy and dosing for pediatric rheumatic disorders
The single-dose pharmacokinetics of midazolam and its primary metabolite in pediatric patients after oral and intravenous administration
Fluoxetine bioequivalence study: quantification of fluoxetine and norfluoxetine by liquid chromatography coupled to mass spectrometry
Use of di(2-ethylhexyl) phthalate-containing medical products and urinary levels of mono(2-ethylhexyl) phthalate in neonatal intensive care unit infants
Exposure to phthalates in neonatal intensive care unit infants: urinary concentrations of monoesters and oxidative metabolites
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Gene expression profiling of DEHP-treated cardiomyocytes reveals potential causes of phthalate arrhythmogenicity
Efficacy and safety of proton pump inhibitors in the management of pediatric gastroesophageal reflux disease
Rectal sedation with diazepam or midazolam during extractions of traumatized primary incisors: a prospective, randomized, double-blind trial in Swedish children aged 1.5-3.5 years
Differences in absorption, distribution, metabolism and excretion of xenobiotics between the paediatric and adult populations
0.5 mg/kg versus 1 mg/kg of intravenous omeprazole for the prophylaxis of gastrointestinal bleeding in critically ill children: a randomized study
Toxicogenomic Screening of Replacements for Di(2-Ethylhexyl) Phthalate (DEHP) Using the Immortalized TM4 Sertoli Cell Line
Screening for children's exposure to environmental tobacco smoke in a pediatric primary care setting
Pharmacokinetics of orally administered omeprazole in children. International Pediatric Omeprazole Pharmacokinetic Group
Positron emission tomography-guided volumetric resection of supratentorial high-grade gliomas: a survival analysis in 66 consecutive patients
A phase I/II study of the safety and pharmacokinetics of nevirapine in HIV-1-infected pregnant Ugandan women and their neonates (HIVNET 006)
Pharmacokinetics of a single oral dose of baclofen in pediatric patients with gastroesophageal reflux disease
Cardiac Collapse Secondary to Phenytoin Toxicity in a Neonate Treated with Extracorporeal Membrane Oxygenation Support (ECMO).
The use of cisapride in children. The North American Society for Pediatric Gastroenterology and Nutrition
Pharmacokinetics of dapsone administered daily and weekly in human immunodeficiency virus-infected children
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Evolution of Pluripotency
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Spatio-Temporal Regulation of DNA Repair
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Archaeal RNA Polymerase
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Central Pontine Myelinolysis
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