Pharmacogenetics of asthma therapy.

Current Pharmaceutical Design
Qing Ling Duan, Kelan G Tantisira

Abstract

Asthma is a chronic disorder causing inflammation and reversible airway obstruction that affects approximately 300 million individuals worldwide. The incidence of asthma has nearly doubled in the past three decades resulting in higher rates of morbidity, mortality and health care costs. Despite the availability of several classes of asthma medications such as beta-agonists, leukotriene modifiers and corticosteroids, up to 50% of asthmatics do not benefit from one or more of these drugs. Studies have shown that asthma and drug response phenotypes such as forced expiratory volume in one second (FEV(1)) are heritable traits, indicating a genetic component of variable response to asthma drugs. This review summarizes the findings of pharmacogenetic investigations on the three main classes of asthma medications. In addition, the limitations of these genetic studies are discussed and future research avenues are proposed to identify novel genetic factors. Although numerous genes have been associated with variable response to common asthma drugs, results are often contradictory across different studies, and remain to be confirmed in larger replication cohorts. Nevertheless, literature in asthma pharmacogenetics demonstrates that genetic...Continue Reading

Citations

Jun 19, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pier Franco Pignatti
May 17, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Frances E Lennon, Patrick A Singleton
Sep 13, 2012·Pharmacogenomics·Amber Dahlin, Kelan G Tantisira
Jun 29, 2014·Paediatric Respiratory Reviews·Mon Ohn, Stephen Jacobe
Jul 12, 2011·Revue des maladies respiratoires·V BellecosteY Pacheco
Mar 23, 2011·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Ahmed M MohamadinFahad A Al-Abbasi

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