Pharmacogenetics of clozapine response and induced weight gain: A comprehensive review and meta-analysis

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
F GressierA Serretti

Abstract

Clozapine (CLZ) is the prototype atypical antipsychotic and it has many advantages over other antipsychotic drugs. Several data suggest that both CLZ response and induced weight gain are strongly determined by genetic variability. However, results remain mainly inconclusive. We aim to review the literature data about pharmacogenetics studies on CLZ efficacy, focusing on pharmacodynamic genes. Further, we performed meta-analyses on response when at least three studies for each polymorphism were available. Sensitivity analyses were conducted on Caucasian population when feasible. Electronic literature search was performed to identify pertinent studies published until May 2014 using PubMed, ISI Web of Knowledge and PsycINFO databases. For meta-analyses, data were entered and analyzed through RevMan version 5.2 using a random-effect model. Our literature search yielded 9266 articles on CLZ; among these, we identified 59 pertinent pharmacogenetic studies. Genotype data were retrieved for 14 polymorphisms in 9 genes. Among these, we had available data from at least three independent samples for 8 SNPs in 6 genes to perform meta-analyses: DRD2 rs1799732, DRD3 rs6280, HTR2A rs6313, rs6311, rs6314, HTR2C rs6318, HTR3A rs1062613, TNFa rs...Continue Reading

References

Jan 1, 1992·The American Journal of Psychiatry·R LeadbetterM Downs
Oct 21, 1995·Lancet·M MasellisJ L Kennedy
Oct 1, 1995·Archives of General Psychiatry·T PollmächerF Holsboer
Dec 1, 1994·The American Journal of Psychiatry·J A LiebermanJ M Kane
Jan 9, 1993·Lancet·S ShaikhA Thornton
Jan 6, 1996·Lancet·D VojvodaC M Mazure
May 1, 1996·The British Journal of Psychiatry : the Journal of Mental Science·R E LitmanD Pickar
Nov 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M RietschelM M Nöthen
Feb 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Y KohnB Lerer
Feb 12, 1998·BMJ : British Medical Journal·M EggerA N Phillips
Jun 18, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M MasellisJ L Kennedy
Jan 26, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J ScharfetterH N Aschauer
May 23, 2000·Lancet·M J ArranzR W Kerwin
May 24, 2000·Molecular Psychiatry·M J ArranzR W Kerwin
Sep 12, 2000·Lancet·J SchumacherM M Nöthen
Jan 3, 2001·European Journal of Pharmacology·J Veenstra-VanderWeeleE H Cook
Oct 5, 2002·Schizophrenia Research·Blanca GutiérrezRobert W Kerwin
Apr 2, 2003·The American Journal of Psychiatry·Gavin P ReynoldsXiaoBin Zhang
Jan 7, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Del D MillerStephan Arndt
Jun 9, 2005·American Journal of Physiology. Endocrinology and Metabolism·James G GrannemanYuyan Lu

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Citations

Apr 23, 2016·Expert Review of Neurotherapeutics·Cheolmin ShinAshwin A Patkar
Mar 13, 2018·Current Opinion in Psychiatry·Clement C ZaiJames L Kennedy
Aug 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Piotr StępnickiAgnieszka A Kaczor
Feb 1, 2018·Der Nervenarzt·D J MüllerUNKNOWN das DGPPN Referat Neurobiologie und Genetik
Dec 30, 2016·Neuroscience Bulletin·Jiangling JiangChunbo Li
Jun 28, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Frederick C NuciforaAkira Sawa
Aug 3, 2016·International Clinical Psychopharmacology·Hui FangXiang Yang Zhang
Oct 16, 2018·Frontiers in Pharmacology·Shusuke NumataRyota Hashimoto
May 2, 2019·Frontiers in Pharmacology·Antonio VitaMassimo Gennarelli
Mar 30, 2017·Western Journal of Nursing Research·Elizabeth Anne BennettMelissa Ann Kalarchian
May 29, 2021·Schizophrenia Research·Amanda J LisowayJames L Kennedy

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