Pharmacogenetics of D2 dopamine receptor gene in prolactin-secreting pituitary adenomas

Expert Opinion on Drug Metabolism & Toxicology
M FilopantiA Spada

Abstract

Dopamine-agonists are the treatment of choice of prolactin-secreting pituitary adenomas (PRL-omas). Their actions on D2 dopamine receptor (DRD2) and the clinical outcome may be affected by polymorphisms. PRL-omas are well-differentiated endocrine tumors expressing DRD2. The dopamine-agonist cabergoline (CB), normalizes prolactin and reduces tumor size in about 80 - 90% of patients. DRD2 polymorphisms correlate with neuropsychiatric disorders, in particular alcoholism and schizophrenia. This review describes the DRD2 polymorphisms, their functional effects, and their impact on susceptibility and response to dopamine-agonists treatment. Searching PubMed database for pertinent articles we found that some DRD2 polymorphisms, particularly TaqIA, TaqIB and NcoI, are associated with different receptor binding in brain areas. One study carried out in patients with PRL-omas found a correlation between NcoI and TaqIA and resistance to CB. In particular, resistant patients had higher prevalence of NcoI-T allele than the responsive patients, while the commonest haplotype (having TaqIA2 allele) was associated with better response. This review deals with the connection between DRD2 polymorphisms and PRL-oma treatment and suggests hypotheses ...Continue Reading

References

Dec 25, 1991·Nucleic Acids Research·A ParsianR D Todd
Sep 1, 1989·The Journal of Clinical Endocrinology and Metabolism·I PellegriniA Enjalbert
Jul 1, 1987·Physiological Reviews·E E Müller
Nov 15, 1993·Biochemical and Biophysical Research Communications·M ItokawaM Toru
Jan 1, 1993·Kidney International·L C RumpP J Schollmeyer
Oct 6, 1993·JAMA : the Journal of the American Medical Association·E P Noble, K Blum
Jun 1, 1996·Pharmacogenetics·D E ComingsR Gade
Oct 18, 1996·The Journal of Biological Chemistry·A CravchikP V Gejman
Oct 1, 1996·Journal of Neuroendocrinology·L CaccavelliA Enjalbert
Mar 6, 1997·Biochemical and Biophysical Research Communications·T PohjalainenJ Hietala
Sep 13, 2001·Clinical Genetics·D E ComingsR J Rosenthal
Jul 13, 2002·Endocrine Pathology·Lucia StefaneanuRudolf Fahlbusch
Dec 24, 2002·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ernest P Noble
Jul 9, 2004·Drug Metabolism Reviews·Ai-Ming YuFrank J Gonzalez
Aug 3, 2004·The British Journal of Psychiatry : the Journal of Mental Science·Ross McD YoungErnest P Noble
May 26, 2005·The Journal of Clinical Endocrinology and Metabolism·M FilopantiA Spada
May 28, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrew W BergenWalter H Kaye
Jan 27, 2006·Genes, Brain, and Behavior·E P Hayden, J I Nurnberger
May 18, 2006·Endocrine Reviews·Mary P GillamAnnamaria Colao
May 30, 2006·Biological Psychiatry·George M AndersonBenedetto Vitiello
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ying ZhangWolfgang Sadée
Feb 9, 2008·Neuroendocrinology·Daniela B RadlDaniel Pisera
Apr 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Agatha A van der KlaauwJohannes A Romijn
Aug 16, 2008·Journal of Psychopharmacology·Peter Fitzgerald, Timothy G Dinan
Jun 27, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Norio Yasui-FurukoriSunao Kaneko

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Citations

Aug 26, 2010·Pharmacogenetics and Genomics·Huaiyu MiRuss B Altman
Feb 25, 2011·Case Reports in Ophthalmology·Hasan RazmjooMohammadreza Akhlaghi
May 29, 2012·Endocrinology·Yunguang TongShlomo Melmed
Oct 31, 2015·Annales d'endocrinologie·Muzaffer IlhanErtugrul Tasan
Nov 1, 2014·Expert Review of Endocrinology & Metabolism·Laurent VroonenAlbert Beckers
Feb 10, 2011·Pharmacological Reviews·Jean-Martin Beaulieu, Raul R Gainetdinov

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