Pharmacogenetics of drug-induced birth defects: what is known so far?

Pharmacogenomics
Bob WilffertLolkje T W de Jong-van den Berg

Abstract

A literature review was performed to collect information on the role of pharmacogenetics in six proposed teratogenic mechanisms associated with drug use during pregnancy: folate antagonism, oxidative stress, angiotensin-converting enzyme inhibition and angiotensin II receptor antagonism, cyclooxygenase-1 and -2 inhibition, 5-hydroxytryptamine-reuptake inhibition and drug transporters in the placenta. Data on the direct relationship between pharmacogenetics and drug-induced birth defects were found for folate metabolism, oxidative stress caused by phenytoin exposure and drug transporters in the placenta. Although no specific data to support pharmacogenetic-related birth defects were found for the NSAIDs, paroxetine and fluoxetine, it might be expected that polymorphisms modify their teratogenic effects. The usually low prevalence of drug-induced malformations impedes the demonstration of the contribution of pharmacogenetics. Large-scale studies, preferably case-control studies, are needed.

References

Oct 1, 1992·Neuropharmacology·R W FullerD W Robertson
Oct 2, 1992·Cell·X JeunemaitreJ M Lalouel
Jun 1, 1993·Teratology·M S YavaroneJ M Lauder
Jun 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·D T WongD W Robertson
May 23, 1998·Annual Review of Pharmacology and Toxicology·J R VaneR M Botting
Jan 23, 1999·Free Radical Biology & Medicine·L M Winn, P G Wells
Mar 24, 1999·Annals of Human Genetics·K MorrisonY H Edwards
May 11, 1999·European Journal of Human Genetics : EJHG·S G HeilH J Blom
Sep 29, 1999·European Journal of Clinical Pharmacology·A EricsonB Wiholm
May 3, 2000·American Journal of Epidemiology·L D Botto, Q Yang
Sep 9, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J M LauderS Singh
Nov 30, 2000·The New England Journal of Medicine·S Hernández-DíazA A Mitchell
May 29, 2001·Current Medicinal Chemistry·P Kovacic, J D Jacintho
Aug 8, 2001·Reproductive Toxicology·A Ericson, B A Källén

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Citations

Nov 7, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·T A Manuck
Apr 5, 2014·Thérapie·Marleen M H J van GelderNel Roeleveld
Oct 24, 2012·Reproductive Toxicology·Jason M Hansen, Craig Harris
Jun 5, 2012·Reproductive Toxicology·Matteo CassinaMaurizio Clementi
Jan 23, 2014·European Journal of Pain : EJP·C FalchB L D M Brücher
Oct 28, 2016·Birth Defects Research. Part C, Embryo Today : Reviews·Peter G AlexanderRocky S Tuan

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Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

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