Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives

Personalized Medicine
Adna AšićDragan Primorac

Abstract

Novel oral anticoagulants (NOACs) are becoming a therapy of choice in everyday clinical practice after almost 50 years during which warfarin and related coumarin derivatives were used as the main anticoagulants. Advantages of NOACs over standard anticoagulants include their predictable pharmacodynamics and pharmacokinetics, stable plasma concentrations and less drug-drug and food-drug interactions. However, pharmacogenetics has its place in administration of NOACs, as considerable interindividual variations have been detected. In this review, previous findings in pharmacogenetics of dabigatran, rivaroxaban, apixaban and edoxaban are summarized, along with recommendations for studying genes encoding metabolically important enzymes for four selected NOACs. Future directions include identification of clinically relevant SNPs, and change in optimum dosage for patients who are carriers of significant variants.

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Citations

Jan 20, 2019·Journal of Personalized Medicine·Sri H Kanuri, Rolf P Kreutz
Dec 21, 2018·Therapeutic Drug Monitoring·Eberhard Wieland, Maria Shipkova
Mar 19, 2019·Therapeutic Drug Monitoring·Eberhard Wieland, Maria Shipkova
Jul 1, 2018·Journal of Personalized Medicine·Munir Pirmohamed
Jan 15, 2021·Journal of Personalized Medicine·Johanna RaymondFabien Lamoureux

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Methods Mentioned

BETA
genotyping
total hip arthroplasty

Software Mentioned

COVER
PubMed
ARISTOTLE
ResearchGate
NOAC
MODEL
RE
NOVATE

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