Pharmacogenomic Testing: Clinical Evidence and Implementation Challenges

Journal of Personalized Medicine
Catriona Hippman, Corey Nislow

Abstract

Pharmacogenomics can enhance patient care by enabling treatments tailored to genetic make-up and lowering risk of serious adverse events. As of June 2019, there are 132 pharmacogenomic dosing guidelines for 99 drugs and pharmacogenomic information is included in 309 medication labels. Recently, the technology for identifying individual-specific genetic variants (genotyping) has become more accessible. Next generation sequencing (NGS) is a cost-effective option for genotyping patients at many pharmacogenomic loci simultaneously, and guidelines for implementation of these data are available from organizations such as the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Dutch Pharmacogenetics Working Group (DPWG). NGS and related technologies are increasing knowledge in the research sphere, yet rates of genomic literacy remain low, resulting in a widening gap in knowledge translation to the patient. Multidisciplinary teams-including physicians, nurses, genetic counsellors, and pharmacists-will need to combine their expertise to deliver optimal pharmacogenomically-informed care.

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Citations

Jun 11, 2020·Healthcare·John StegelmeierJared Barrott
Mar 27, 2020·Journal of Multidisciplinary Healthcare·Suhaib MuflihKarem H Alzoubi
Jan 22, 2021·Digestive Diseases and Sciences·Dana M HarrisYan Bi
Dec 31, 2020·Journal of Personalized Medicine·Samantha BreauxCorey Nislow
Feb 25, 2021·Expert Opinion on Drug Metabolism & Toxicology·Irene García-García, Alberto M Borobia
Feb 20, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Amina M BagherSara M Bagher
Apr 3, 2021·American Journal of Human Genetics·Gregory McInnesRuss B Altman
Apr 3, 2021·Therapeutic Advances in Drug Safety·Aisling R Caffrey, Eric P Borrelli
Apr 4, 2021·Journal of Personalized Medicine·Jeeyun A KimChristine Y Lu
Jun 3, 2021·Journal of Personalized Medicine·Benjamin LaplaceEric Charles
Sep 7, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Cyrine-Eliana HaidarJames M Hoffman

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Methods Mentioned

BETA
exome sequencing

Software Mentioned

ClinVar
fasta
PharmGKB

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