Pharmacogenomics for Primary Care: An Overview.

Genes
Victoria RollinsonMunir Pirmohamed

Abstract

Most of the prescribing and dispensing of medicines happens in primary care. Pharmacogenomics (PGx) is the study and clinical application of the role of genetic variation on drug response. Mounting evidence suggests PGx can improve the safety and/or efficacy of several medications commonly prescribed in primary care. However, implementation of PGx has generally been limited to a relatively few academic hospital centres, with little adoption in primary care. Despite this, many primary healthcare providers are optimistic about the role of PGx in their future practice. The increasing prevalence of direct-to-consumer genetic testing and primary care PGx studies herald the plausible gradual introduction of PGx into primary care and highlight the changes needed for optimal translation. In this article, the potential utility of PGx in primary care will be explored and on-going barriers to implementation discussed. The evidence base of several drug-gene pairs relevant to primary care will be outlined with a focus on antidepressants, codeine and tramadol, statins, clopidogrel, warfarin, metoprolol and allopurinol. This review is intended to provide both a general introduction to PGx with a more in-depth overview of elements relevant to ...Continue Reading

References

Jan 1, 1986·Journal of Cardiovascular Pharmacology·G Leopold
May 1, 1981·Journal of Clinical Pharmacology·K A Conrad
Jul 1, 1980·Acta Pharmacologica Et Toxicologica·J HyttelB Fjalland
Sep 28, 2001·British Journal of Anaesthesia·D G WilliamsR F Howard
Aug 13, 2002·Pharmacogenetics·Thomas RauThomas Eschenhagen
Aug 13, 2002·Journal of Clinical Psychopharmacology·Kazutaka ShimodaMasako Okawa
Sep 12, 2002·Clinical Pharmacokinetics·Zeruesenay DestaDavid A Flockhart
Feb 7, 2003·The New England Journal of Medicine·William E Evans, Howard L McLeod
Nov 19, 2003·Metabolism: Clinical and Experimental·Jürgen BorlakThomas Thum
Jul 3, 2004·BMJ : British Medical Journal·Munir PirmohamedAlasdair M Breckenridge
Jul 31, 2004·Pharmacogenetics·Kari T KivistöTimo Strandberg
Oct 29, 2004·Clinical Pharmacokinetics·Stefan Grond, Armin Sablotzki
Dec 31, 2004·The New England Journal of Medicine·Yvan GascheJules Desmeules
Jun 30, 2005·Current Opinion in Allergy and Clinical Immunology·Eva Rebelo Gomes, Pascal Demoly
Apr 25, 2006·Journal of Clinical Psychopharmacology·Cüneyt Güzey, Olav Spigset
Jun 29, 2006·British Journal of Clinical Pharmacology·R L HowardM Pirmohamed
Sep 9, 2006·Journal of Clinical Pharmacy and Therapeutics·M E E ShamsS Härtter
Feb 10, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Piergiorgio ZuccaroCesare R Sirtori
Oct 9, 2007·Journal of the American Academy of Dermatology·Sima HalevyUNKNOWN EuroSCAR Study Group
Dec 12, 2007·British Journal of Clinical Pharmacology·Monique J BijlRon H N van Schaik
Jan 22, 2008·Journal of Clinical Psychopharmacology·Julia KirchheinerJürgen Brockmöller
Feb 8, 2008·The New England Journal of Medicine·Simon MallalUNKNOWN PREDICT-1 Study Team
Feb 26, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ine Blankenberg SkottheimAnders Asberg
Jul 25, 2008·The New England Journal of Medicine·UNKNOWN SEARCH Collaborative GroupR Collins
Aug 13, 2008·Analytical and Bioanalytical Chemistry·Ulrich M ZangerMatthias Schwab
Aug 21, 2008·Anesthesia and Analgesia·Ulrike M StamerFrank Musshoff
Sep 12, 2008·Clinical Pharmacology and Therapeutics·M J BijlB H Ch Stricker
Nov 28, 2008·Clinical Pharmacology and Therapeutics·T RauT Eschenhagen
Dec 25, 2008·The New England Journal of Medicine·Jessica L MegaMarc S Sabatine
Feb 21, 2009·The New England Journal of Medicine·UNKNOWN International Warfarin Pharmacogenetics ConsortiumJ A Johnson
May 2, 2009·Science·Sarah A TishkoffScott M Williams
May 29, 2009·Clinical Pharmacology and Therapeutics·J E KeskitaloM Niemi
Jun 2, 2009·Nature Genetics·Ann K DalyUNKNOWN International SAE Consortium
Jun 11, 2009·Pharmacogenetics and Genomics·Caroline F ThornRuss B Altman
Oct 6, 2009·Pharmacoepidemiology and Drug Safety·Matthijs L BeckerBruno H Ch Stricker
Oct 9, 2009·Nature·Teri A ManolioPeter M Visscher
Oct 17, 2009·Journal of the American College of Cardiology·Deepak VooraGeoffrey S Ginsburg

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Citations

Dec 10, 2020·Genes·Maaike van der LeeJesse J Swen
Apr 20, 2021·Frontiers in Pharmacology·Rodrigo José Vargas, Oscar M Cobar

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Methods Mentioned

BETA
genotyping
exome sequencing

Software Mentioned

POPular Genetics
PGx CDSS
PGx
SystemOne
POPular
PREPARE

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