Pharmacogenomics for the efficacy of platinum-based chemotherapy: Old drugs, new integrated perspective.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Chen-Xue MaoZhao-Qian Liu

Abstract

Platinum-based chemotherapy remains the cornerstone of treatment for many malignancies. However, although therapeutic efficiency varies greatly among individuals, there is a lack of pharmacogenomic biomarkers that can be used in clinical settings to identify chemosensitive patients and allow stratification. With the development of high-throughput screening techniques and systems biology approaches, a growing body of evidence has shown that platinum resistance is a multifactorial, multi-dimensional, dynamic process incorporating genetic background, tumor evolution and gut microbes. This review critically summarizes potential pharmacogenomic biomarkers for predicting the efficacy of platinum drugs and provides a comprehensive, time-varying perspective that integrates multiple markers.

References

Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E ReedM C Poirier
Jun 11, 1996·International Journal of Cancer. Journal International Du Cancer·G DamiaM D'Incalci
Jan 9, 1997·Nature·R J CoteD G Skinner
Jul 7, 2000·The Journal of Biological Chemistry·I KuraokaR D Wood
Jul 10, 2003·Critical Reviews in Oncology/hematology·Richard J Cote, Ram H Datar
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kentaro NakayamaYuji Takebayashi
Jun 19, 2004·Cancer Research·M Eileen DolanJudith A Badner
Jul 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Goli SamimiStephen B Howell
Nov 18, 2004·Journal of the National Cancer Institute·Richard D KennedyD Paul Harkin
Aug 12, 2006·Science·Jean-Philippe NougayrèdeEric Oswald
Mar 16, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L TailladeJ-C Soria
Oct 3, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Richard BootonNick Thatcher
Apr 17, 2008·Cancer Research·Elizabeth M SwisherToshiyasu Taniguchi
Nov 11, 2008·Molecular Pharmacology·Christopher A LarsonStephen B Howell
Mar 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Friedemann HoneckerLeendert H J Looijenga
Sep 3, 2009·Cancer Research·Nikhil R BhagwatLaura J Niedernhofer
Apr 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter C FongStan B Kaye
Oct 12, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Corinne M DollAnthony M Magliocco
Nov 16, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ming YinQingyi Wei
Nov 17, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yasunori SatoTomohide Tamura
Jan 14, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P M L H VenckenC Seynaeve
Apr 19, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Dana ZiliakR Stephanie Huang
Jun 29, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara NorquistElizabeth M Swisher
Jul 14, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Luc FribouletJean-Charles Soria
Jul 22, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiang-Lin TanLiewei Wang
Mar 29, 2012·The New England Journal of Medicine·Jonathan LedermannUrsula Matulonis
Jun 20, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathryn AlsopGillian Mitchell
Aug 9, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lingmin HuHongbing Shen
Aug 24, 2012·Molecular Cancer Therapeutics·Zheng D LiangMacus Tien Kuo
Mar 22, 2013·The New England Journal of Medicine·Luc FribouletJean-Charles Soria

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