Pharmacogenomics for the forensic toxicologist

Journal of Analytical Toxicology
Thomas C KupiecNicole Vu

Abstract

Pharmacogenomics is the study of the linkage between an individual's genotype and the disposition of drugs in the body. The first association between adverse drug reactions and inherited variations was recognized in the 1950s, and since then, pharmacogenomics has come a long way. The importance of pharmacogenomics is accentuated by the incidence of adverse drug reactions, which may account for hospital expenditures of up to 5.6 billion dollars annually. Interindividual variations in drug metabolism are often the result of genetic variants or genetic polymorphisms, and polymorphisms have been known to alter the relationship between dose and plasma drug concentration. Drug disposition can be affected by polymorphisms in drug metabolizing enzymes, drug transport proteins, and drug targets. The cytochrome P450 (CYP) enzymes are responsible for the metabolism of a large number of drugs. Polymorphisms of the CYP enzymes have been well documented, and CYP2D6 is the most polymorphic CYP enzyme. However, there is a relative dearth of research on the role of transport proteins and drug targets. This review attempts to provide a brief synopsis of the pharmacogenomics of some common drug-metabolizing enzymes, transport proteins, and target...Continue Reading

Citations

Mar 2, 2016·Forensic Science International : Synergy·Suzana FonsecaMário Dias
Dec 20, 2011·Legal Medicine·Cristian PalmiereFrank Sporkert
Sep 11, 2010·Forensic Science International : Synergy·Frank MusshoffBurkhard Madea
May 4, 2016·Journal of Forensic and Legal Medicine·Selma J M Eikelenboom-SchieveldJames C Fogleman
Jun 14, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Mansour S Al-SaidHusnu C Baser
May 27, 2017·International Journal of Molecular Sciences·Andrés López-CortésLuis Abel Quiñones
Oct 9, 2020·Journal of Analytical Toxicology·Jirair GevorkyanLuke N Rodda
Dec 6, 2020·Forensic Science International. Genetics·G DrevinC Abbara

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