Pharmacogenomics of genetic polymorphism within the genes responsible for SARS-CoV-2 susceptibility and the drug-metabolising genes used in treatment.

Reviews in Medical Virology
Laith N Al-Eitan, Saif Z Alahmad

Abstract

The ongoing outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a significant challenge to international health. Pharmacogenomics aims to identify the different genetic variations that exist between individuals and populations in order to determine appropriate treatment protocols to enhance the efficacy of drugs and reduce their side-effects. This literature review provides an overview of recent studies of genetic polymorphisms in genes that mediate the SARS-CoV-2 infection mechanism (ACE1, ACE2, TMPRSS2 and CD26). In addition, genetic variations in the drug-metabolising enzyme genes of several selected drugs used in the treatment of COVID-19 are summarised. This may help construct an effective health protocol based on genetic biomarkers to optimise response to treatment. Potentially, pharmacogenomics could contribute to the development of effective high-throughput assays to improve patient evaluation, but their use will also create ethical, medical, regulatory, and legal issues, which should now be considered in the era of personalised medicine.

References

Sep 24, 2004·Biochemical and Biophysical Research Communications·Satoru ItoyamaTakehiko Sasazuki
May 3, 2007·Clinical Pharmacology and Therapeutics·X FanUNKNOWN Study Group for Pharmacogenomic Based Antihypertensive Drugs Selection, Effects and Side Effects, in Rural Area Chinese
Jan 23, 2008·Genetical Research·Y B SaabA D J Overall
Oct 8, 2008·Annals of the New York Academy of Sciences·Samir AttoubGeorg Petroianu
Nov 19, 2009·Biochemical and Biophysical Research Communications·Yeqing TongZuxun Lu
Jan 12, 2011·Clinical Reviews in Allergy & Immunology·Ilan Ben-ZviYehuda Shoenfeld
Dec 24, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Koen Vandenbroeck
Apr 23, 2013·Lancet Neurology·Thiravat HemachudhaJiraporn Laothamatas
Jun 2, 2016·Pharmacogenomics·Antonio D'AvolioGiovanni Di Perri
Oct 22, 2016·Pharmacogenomics·Vinicius A SorticaMara H Hutz
Dec 14, 2016·World Journal of Gastroenterology : WJG·Dong-Ying XieDa-Ru Lu
Jan 11, 2017·European Journal of Drug Metabolism and Pharmacokinetics·Hazem Elewa, Kyle John Wilby
Jul 1, 2017·Science Translational Medicine·Timothy P SheahanRalph S Baric
Nov 28, 2017·Bioorganic & Medicinal Chemistry Letters·Nikolay I ZhuriloVitaly I Shvets
May 1, 2014·Personalized Medicine·Elena López AspirozThe Tormes Team
Apr 17, 2019·Viruses·Egor P TchesnokovMatthias Götte
Aug 14, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Masami DoiTetsuya Aiba
Oct 5, 2019·The Medical Clinics of North America·Dyson T WakePeter J Hulick
Jan 19, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·David S HuiEskild Petersen
Feb 9, 2020·Nature Reviews. Rheumatology·Eva Schrezenmeier, Thomas Dörner
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Mar 7, 2020·Gastroenterology·Fei XiaoHong Shan
Mar 8, 2020·International Journal of Antimicrobial Agents·Philippe ColsonDidier Raoult

❮ Previous
Next ❯

Citations

Dec 16, 2020·Viruses·Laith N Al-EitanAnthony R Fooks
Aug 24, 2021·Frontiers in Medicine·Alfonso J Rodriguez-MoralesMatthew H Collins

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Médecine sciences : M/S
Marie-Anne Loriot, Philippe Beaune
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
G Tsujimoto
Indian Journal of Pharmacology
Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Junichi Azuma, Kenichi Imagawa
© 2021 Meta ULC. All rights reserved