Pharmacogenomics of metabotropic glutamate receptor subtype 1 and in vivo malignant melanoma formation

The Journal of Dermatology
M Abdel-DaimC Nishigori

Abstract

We have previously shown that ectopic expression of metabotropic glutamate receptor subtype 1 in melanocytes is essential for both development and in vivo growth of melanoma using newly developed transgenic mice which conditionally express metabotropic glutamate receptor subtype 1 (mGluR1). In this study, we developed conditional transgenic mice, which harbor melanocytes not only in the dermis and hair follicles but also in the epidermis using stem cell factor transgenic mice. Pigmented plaques on the backs, tails, ears or groins of the transgenic mice began to appear 13 weeks after activation of the mGluR1 transgene, and the transgenic mice produced melanomas at a frequency of 100% 36 weeks after transgene activation. Although this transgenic mouse harbors melanocytes in the epidermis, proliferation of melanoma cells took place in the dermis. To elucidate the signals involved in development and growth of melanoma, inhibitors to phospholipase C, protein kinase C and mitogen-activated protein kinase kinase 1/2, and antagonists to Ca(2+) and calmodulin were administrated to transgenic mice. Each signal inhibitor to phospholipase, protein kinase C, Ca(2+) release, calmodulin and mitogen-activated protein kinase kinase 1/2 inhibite...Continue Reading

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Citations

Sep 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kyu Yeong ChoiKatherine W Roche
Oct 12, 2011·Pigment Cell & Melanoma Research·Graeme J WalkerNeil F Box
Aug 29, 2013·International Journal of Biological Sciences·Stacey S Willard, Shahriar Koochekpour
Jun 15, 2012·The Journal of Investigative Dermatology·Herlina Y HandokoGraeme J Walker
Nov 11, 2016·BMC Complementary and Alternative Medicine·Amalia Di PetrilloAntonella Fais
Aug 11, 2017·BMC Complementary and Alternative Medicine·Chi-Chung PengJen-Chieh Li
Oct 4, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Shuang ZhaoLisha Wu
Jun 3, 2021·Cancers·Cristian ScheauConstantin Caruntu
Aug 8, 2021·Cancers·Kevinn Eddy, Suzie Chen

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