PMID: 15379653Sep 24, 2004Paper

Pharmacogenomics: the influence of genomic variation on drug response

Current Topics in Medicinal Chemistry
Fabienne J ThomasJames W Watters

Abstract

Unpredictable efficacy and toxicity are major hurdles in the administration of many medications. By identifying inherited DNA polymorphisms that influence drug disposition and effects, pharmacogenomics is an exciting tool for the individualization of drug therapies. Single nucleotide polymorphisms (SNP) in genes encoding drug metabolizing enzymes, drug transporters, and DNA repair genes have recently been shown to influence drug toxicity and efficacy. This review will discuss clinically relevant examples of genetic polymorphisms that influence the outcome of drug therapy, and possibilities for future applications of pharmacogenomics.

Citations

Apr 6, 2006·Human Genomics·Sevtap SavasHilmi Ozcelik
Jul 26, 2005·Journal of Human Genetics·Barkur S Shastry
Mar 15, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Primus-E Mullis
Sep 11, 2007·Drug Metabolism and Pharmacokinetics·Steven N HartXiao-bo Zhong
Aug 23, 2016·Pharmacogenomics·Judit KumuthiniAlessio Squassina
Nov 15, 2008·BioTechniques·Shannon BruseLinda Brzustowicz

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