Pharmacogenomics

Lancet
Dan M RodenSara L Van Driest

Abstract

Genomic medicine, which uses DNA variation to individualise and improve human health, is the subject of this Series of papers. The idea that genetic variation can be used to individualise drug therapy-the topic addressed here-is often viewed as within reach for genomic medicine. We have reviewed general mechanisms underlying variability in drug action, the role of genetic variation in mediating beneficial and adverse effects through variable drug concentrations (pharmacokinetics) and drug actions (pharmacodynamics), available data from clinical trials, and ongoing efforts to implement pharmacogenetics in clinical practice.

Citations

Oct 24, 2019·The New England Journal of Medicine·Dan M Roden
Jan 16, 2020·BMJ : British Medical Journal·Robin Ferner, Patricia McGettigan
Jan 21, 2020·Expert Review of Clinical Pharmacology·Michele MussapVassilios Fanos
Feb 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Anastacia M GarciaStephanie J Nakano
Jul 24, 2020·Blood·Lucio LuzzattoRosario Notaro
Jun 3, 2020·Fortschritte der Neurologie-Psychiatrie·Lara Stute, Rejko Krüger
Jun 2, 2020·The Bone & Joint Journal·William G HamiltonNancy L Parks
Jul 4, 2020·Clinical Rheumatology·Laura L DanielCecilia P Chung
Sep 11, 2020·Journal of Clinical Medicine·Sylvia D KlompJesse J Swen
Sep 20, 2020·The Pharmacogenomics Journal·Marcela ForgeriniPatrícia de Carvalho Mastroianni
Jan 28, 2020·Lung Cancer Management·Chrysanthi SardeliKonstantinos Sapalidis
Sep 15, 2020·Frontiers in Cardiovascular Medicine·Sherry-Ann BrownVijay U Rao
Sep 10, 2020·Risk Management and Healthcare Policy·Mohammed Algahtani
Feb 13, 2020·High-throughput·Giuseppe NovelliMarisa Papaluca
Sep 16, 2020·International Journal of Molecular Sciences·Zulfan ZazuliRosalinde Masereeuw
Jul 8, 2020·International Journal of Molecular Sciences·Claudia Maria HattingerMassimo Serra
Oct 14, 2020·Clinical and Translational Science·Timothy A RobertsStephani L Stancil
Nov 10, 2020·Clinical and Translational Science·Karla Claudio-CamposCarol A Mathews
Dec 1, 2020·Journal of Managed Care & Specialty Pharmacy·David BrightSreekanth Chavour
Dec 11, 2020·Pain Management·Nicholas J ConnorsHong K Kim
Jan 5, 2021·Deutsche medizinische Wochenschrift·Simon JägerMatthias Schwab
Oct 14, 2020·Annual Review of Pharmacology and Toxicology·Saad KhanLibusha Kelly
Nov 5, 2019·Trends in Pharmacological Sciences·Tatiana V Tkatchenko, Andrei V Tkatchenko
Oct 25, 2020·Drug Metabolism and Pharmacokinetics·Takeshi MasudaSumio Ohtsuki
Oct 16, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael ZhongVilija Jokubaitis
Feb 24, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Sonam N ShahDavid W Bates
Mar 25, 2021·JAMA : the Journal of the American Medical Association·Kimberly Maxfield, Issam Zineh
Mar 23, 2021·Age and Ageing·Sarah N Hilmer, Carl M J Kirkpatrick
Apr 8, 2021·Pediatric Research·Sonya C Tang GirdwoodLaura B Ramsey
Apr 15, 2021·Pharmacogenomics·Stephani L StancilSusan Abdel-Rahman
Apr 30, 2021·Expert Opinion on Pharmacotherapy·Ram BrenderDaniel M Blumberger
May 1, 2021·International Journal of Molecular Sciences·Maria TziastoudiTheoharis C Theoharides

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