PMID: 11318430Apr 25, 2001Paper

Pharmacokinetic analysis by high-performance liquid chromatography of intravenous nordihydroguaiaretic acid in the mouse

Journal of Chromatography. B, Biomedical Sciences and Applications
J D LambertRobert T Dorr

Abstract

Nordihydroguaiaretic acid (NDGA) has been shown to inhibit both 5-lipoxygenase and ornithine decarboxylase and is active against several cancer cell lines and at least one mouse tumor model. Despite these findings, there have been no reports on the pharmacokinetics of NDGA. A reverse-phase high-performance liquid chromatography (HPLC) method was developed to detect NDGA in mouse plasma. The limit of detection of this method was 0.5 microg/ml. Administration of NDGA (50 mg/kg, i.v.) to mice resulted in a peak plasma concentration of 14.7 microg/ml. The terminal half-life of NDGA was 135.0 min with a clearance of 201.9 ml/min x kg.

Citations

Mar 20, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Hui-Jin SungKoji Ogawa
Aug 4, 2001·Cancer Letters·J D LambertR T Dorr
Nov 1, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jian-Ming LüChangyi Chen
Feb 9, 2016·Seminars in Cancer Biology·Nagendra Sastry YarlaGovinda Rao Duddukuri
Oct 2, 2007·Gynecologic Oncology·Niharika KhannaNeil Frazer
Nov 6, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jesper Østergaard, Claus Larsen
Oct 24, 2019·Current Cancer Drug Targets·Geraldine Sandana Mala JohnSuresh Kumar Rayala

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