Pharmacokinetic analysis of pegylated megakaryocyte growth and development factor in humans

Growth Factors
R H De BoerJ Cebon

Abstract

Phase I studies with pegylated megakaryocyte growth and development factor (PEG-rHuMGDF), a c-Mpl ligand that stimulates megakaryopoiesis, have demonstrated that PEG-rHuMGDF is biologically active alone and causes a dose-related enhancement of platelet recovery when administered after chemotherapy. Here we report the dose-ranging pharmacokinetics of PEG-rHuMGDF. Pre-injection blood samples were drawn daily for pharmacokinetic studies on 43 patients. An ELISA, established using PEG-rHuMGDF as the standard, was able to quantitate Mpl ligand at concentrations > 0.02 ng/mL. Over the dose range 0.03 to 5.0 microg/kg/day, subcutaneous administration produced linear increases in steady-state serum levels. Maximum levels of PEG-rHuMGDF attained after 5.0 microg/kg/day were 5.88 to 10.9 ng/mL. After discontinuation of PEG-rHuMGDF, concentrations of Mpl ligand returned to baseline within 5 days. The pharmacokinetics were best described by a one-compartment model with first-order absorption, an absorption delay, and non linear clearance over the first 48 hours. The mean terminal half-life was 33.3 + 16.7 hours, and the average apparent at steady state was 27.7 + 14.0 mL/h/kg; both were independent of administered dose. The apparent cleara...Continue Reading

References

Mar 1, 1991·Clinical Pharmacology and Therapeutics·F J MeyersM Konrad
Jul 1, 1995·Journal of Biochemistry·T KatoE Maeda

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Citations

Jun 8, 2002·Advanced Drug Delivery Reviews·Olaf KinstlerColin Gegg
Jun 19, 2010·Regulatory Toxicology and Pharmacology : RTP·Jay TibbittsJohn T Sullivan
Aug 13, 2009·Advanced Drug Delivery Reviews·Gianfranco Pasut, Francesco M Veronese
Apr 1, 2004·Expert Opinion on Therapeutic Patents·Nicolò Pipitone, Costantino Pitzalis

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