Pharmacokinetic and behavioural profile of THC, CBD, and THC+CBD combination after pulmonary, oral, and subcutaneous administration in rats and confirmation of conversion in vivo of CBD to THC

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Tomáš HložekTomáš Páleníček

Abstract

Metabolic and behavioural effects of, and interactions between Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are influenced by dose and administration route. Therefore we investigated, in Wistar rats, effects of pulmonary, oral and subcutaneous (sc.) THC, CBD and THC+CBD. Concentrations of THC, its metabolites 11-OH-THC and THC-COOH, and CBD in serum and brain were determined over 24h, locomotor activity (open field) and sensorimotor gating (prepulse inhibition, PPI) were also evaluated. In line with recent knowledge we expected metabolic and behavioural interactions between THC and CBD. While cannabinoid serum and brain levels rapidly peaked and diminished after pulmonary administration, sc. and oral administration produced long-lasting levels of cannabinoids with oral reaching the highest brain levels. Except pulmonary administration, CBD inhibited THC metabolism resulting in higher serum/brain levels of THC. Importantly, following sc. and oral CBD alone treatments, THC was also detected in serum and brain. S.c. cannabinoids caused hypolocomotion, oral treatments containing THC almost complete immobility. In contrast, oral CBD produced mild hyperlocomotion. CBD disrupted, and THC tended to disrupt PPI, however their com...Continue Reading

Citations

Feb 23, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Theodore A SlotkinFrederic J Seidler
Mar 19, 2020·Pharmaceutics·Fabrizio CalapaiCarmen Mannucci
Feb 26, 2020·Substance Use & Misuse·Meghann WheelerHanadi Hamadi
Feb 8, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jyotpal Singh, John Patrick Neary
Dec 21, 2018·Archives of Toxicology·Timothy E HoffmanWilliam H Hanneman
May 22, 2019·Scientific Reports·Matthew W ElmesMartin Kaczocha
Jul 28, 2020·International Journal of Molecular Sciences·Dongchen AnJan Tytgat
Apr 24, 2020·Cannabis and Cannabinoid Research·James M Nichols, Barbara L F Kaplan
Sep 22, 2018·Psychopharmacology·Nicholas Z GreeneRebecca M Craft
Jun 5, 2019·Current Neuropharmacology·Marilyn A HuestisFrancesco Paolo Busardò
Apr 24, 2020·Cannabis and Cannabinoid Research·José Alexandre S CrippaLiberato Brum Junior
Dec 13, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hanna J SzkudlarekSteven R Laviolette
Oct 1, 2020·International Journal of Molecular Sciences·Olga SadowskaHanna Kozłowska
Sep 18, 2020·International Journal of Molecular Sciences·Aleksandra Kicman, Marek Toczek
Sep 29, 2020·British Journal of Pharmacology·Claire M Williams, Gary J Stephens
Oct 19, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jia SunDa-Wei Ye
Dec 22, 2020·Neurobiology of Stress·Nicholas C GlodoskyRyan J McLaughlin
Feb 9, 2021·Frontiers in Behavioral Neuroscience·Giselda Cabral-PereiraRicardo Gómez-Nieto
Mar 24, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Zaid H MaayahJason R B Dyck
Mar 21, 2021·Neuropharmacology·Vanessa A MitchellChristopher W Vaughan
May 2, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jan VacekMichal Masarik
Oct 24, 2019·Pharmacology, Biochemistry, and Behavior·Alejandra MondinoDaniella Agrati
Apr 24, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Zacharias PandelidesKristine L Willett
May 26, 2021·Journal of Translational Medicine·Aymen H SadakaCraig F Ferris
Jun 12, 2021·Neuropharmacology·Gavin N PetrieMatthew N Hill
Jul 13, 2021·Epilepsia·Merrick S FallahW McIntyre Burnham
Jul 16, 2021·Journal of the International Neuropsychological Society : JINS·C Wei-Ming WatsonIgor Grant
Aug 3, 2021·The International Journal of Neuropsychopharmacology·Benjamin Z RobertsJared W Young

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.