PMID: 8632706Jan 1, 1996Paper

Pharmacokinetic and pharmacodynamic optimization of intraperitoneal chemotherapy

Life Sciences
J P Balthasar, H L Fung

Abstract

Intraperitoneal drug administration has been utilized to increase chemotherapeutic exposure to tumors confined to the peritoneal cavity, such as those found in ovarian, gastric, colo-rectal and mesotheliomal cancers. Extensive pre-clinical and clinical experimentation has been conducted to assess the pharmacokinetic and therapeutic benefits of this mode of therapy. Pharmacokinetic studies have shown that the barrier function of the peritoneal membrane may be utilized to produce large, favorable concentration gradients between peritoneal perfusate and blood. However, most clinical studies so far have demonstrated minimal increases in drug efficacy or decreases in drug toxicities from intraperitoneal drug therapy alone. This paper reviews the application of adjunctive therapies that have been rationally conceived to optimize intraperitoneal drug therapy through the alteration of antineoplastic pharmacokinetics and pharmacodynamics.

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G M HahnI Har-Kedar
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·E B Mechetner, I B Roninson
Mar 1, 1990·Gynecologic Oncology·P PfeifferK Bertelsen
Jun 15, 1989·Cancer·M J Wizenberg
Jan 1, 1985·International Journal of Nuclear Medicine and Biology·R E GibsonR Eng
Nov 1, 1986·Journal of Pharmaceutical Sciences·R L Dedrick
Jan 1, 1985·Journal of Oral Rehabilitation·S E WidmalmJ H Lillie
Dec 1, 1982·Annals of Internal Medicine·S B HowellM Green
Nov 1, 1994·Clinical Pharmacokinetics·K D Bagshawe
Dec 1, 1993·International Journal of Radiation Oncology, Biology, Physics·K A LeopoldM W Dewhirst
May 1, 2013·Angewandte Chemie·Gang LiuHui-Ming Cheng

Citations

Nov 10, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·K NishidaJ Nakamura
Mar 17, 2012·Clinical Pharmacokinetics·Csilla Hasovits, Stephen Clarke
Mar 27, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Pierre-Emmanuel ColomboM Vert
Dec 13, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B J Monk, J K Chan

Related Concepts

Antineoplastic Agents
Drug Carriers
Parenteral Infusion
Peritoneal Neoplasms

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