Pharmacokinetic and pharmacodynamic considerations of general anesthesia in pediatric subjects.

Expert Opinion on Drug Metabolism & Toxicology
Brian J AndersonL Ignacio Cortinez

Abstract

Introduction: The target concentration strategy uses PKPD information for dose determination. Models have also quantified exposure-response relationships, improved understanding of developmental pharmacokinetics, rationalized dose prescription, provided insight into the importance of covariate information, explained drug interactions and driven decision-making and learning during drug development.Areas covered: The prime PKPD consideration is parameter estimation and quantification of variability. The main sources of variability in children are age (maturation) and weight (size). Model use is mostly confined to pharmacokinetics, partly because anesthesia effect models in the young are imprecise. Exploration of PK and PD covariates and their variability hold potential to better individualize treatment.Expert opinion: The ability to model drugs using computer-based technology is hindered because covariate data required to individualize treatment using these programs remain lacking. Target concentration intervention strategies remain incomplete because covariate information that might better predict individualization of dose is absent. Pharmacogenomics appear a valuable area for investigation for pharmacodynamics and pharmacodynam...Continue Reading

References

Jan 1, 1977·Clinical Pharmacokinetics·T F Blaschke
Mar 1, 1979·Clinical Pharmacology and Therapeutics·L B SheinerJ Ham
Mar 29, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·A Reinberg, M A Reinberg
Aug 1, 1991·British Journal of Clinical Pharmacology·M MustofaB Santoso
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·W J Dixon
Aug 1, 1990·British Journal of Anaesthesia·F ServinJ M Desmonts
Nov 1, 1986·Anesthesia and Analgesia·N G Goudsouzian, F G Standaert
May 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·F KamaliG D Bell
May 1, 1987·Clinical Pharmacokinetics·M OllagnierA Reinberg
Dec 1, 1981·British Journal of Anaesthesia·N G GoudsouzianI D Todres
Jan 1, 1981·European Journal of Clinical Pharmacology·J ClenchM Smolensky
Jan 1, 1993·Developmental Pharmacology and Therapeutics·M L PokelaM Koivisto
Nov 1, 1995·Clinical Pharmacokinetics·N H Holford
Mar 1, 1997·Anaesthesia·L DavisM Morgan
Jun 1, 1997·British Journal of Anaesthesia·J M WierdaJ H Proost
Feb 10, 1999·Anesthesiology·B J AndersonM Mahadevan
Jun 9, 1999·Anesthesiology·T W SchniderE J Youngs
Oct 28, 1999·International Journal of Pharmaceutics·M HalsasM Marvola
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·P L Chan, N H Holford
Jan 5, 2002·European Journal of Clinical Pharmacology·B J AndersonN H Holford
Mar 21, 2002·Paediatric Anaesthesia·Brian J Anderson, George H Meakin
Oct 4, 2002·Journal of Pharmacokinetics and Pharmacodynamics·Vladimir Nigrovic, Anton Amann
Sep 17, 2003·The Journal of Pharmacology and Experimental Therapeutics·Jeffrey C StevensMatthew J Zaya
Apr 20, 2004·Advances in Experimental Medicine and Biology·Charles Minto, Jaap Vuyk
Mar 25, 2005·Paediatric Anaesthesia·Brian J AndersonEric Boccard
Jun 14, 2005·British Journal of Clinical Pharmacology·Terence Stephenson
Jul 13, 2005·Prostate Cancer and Prostatic Diseases·J L BoddyP R Malone
Sep 24, 2005·Paediatric Anaesthesia·Brian Anderson, Noel Cranswick
Jun 29, 2006·Clinical Pharmacokinetics·Jeroen W B PetersDick Tibboel
Jun 30, 2006·European Journal of Pediatrics·Brian J AndersonNicholas H G Holford
Jun 30, 2006·European Journal of Pediatrics·Brian J AndersonNicholas H G Holford

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