PMID: 2114952Mar 1, 1990Paper

Pharmacokinetic behavior of ciprofloxacin both in native cardiac and porcine valves treated in glutaraldehyde

Diagnostic Microbiology and Infectious Disease
P KalmárT Menzel

Abstract

When judging a probable therapeutic success for antibiotic management of bioprosthetic endocarditis, sufficient drug levels in heterologous valve tissues play a very important role. The pharmacokinetic behavior of ciprofloxacin was investigated in native and porcine valvular tissues and compared with plasma levels during a 90- to 120-min period of surgery. Analysis was carried out by HPLC using excised valvular tissues (Hancock T 505). In all, 15-20 patients were investigated in each group. The antibiotics were administered intravenously or per os. Tissue concentrations after onset of the procedures showed ciprofloxacin plasma concentrations of 2.09-0.47 micrograms g in the native and 3.98-1.99 micrograms/g in the heterologous valvular tissues.

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Citations

Feb 27, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Donald P LevineKenneth Tack

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