Pharmacokinetic behavior of marbofloxacin after intravenous and intramuscular administrations in adult goats

Journal of Veterinary Pharmacology and Therapeutics
S WaxmanM D San Andrés

Abstract

The pharmacokinetic behavior of marbofloxacin was studied in goats after single-dose intravenous (i.v.) and intramuscular (i.m.) administrations of 2 mg/kg bodyweight. Drug concentration in plasma was determined by high performance liquid chromatography (HPLC) and the data collected were subjected to compartmental and noncompartmental kinetic analysis. This compound presented a relatively high volume of distribution (Vss=1.31 L/kg), which suggests good tissue penetration, and a total body clearance (Cl) of 0.23 L/kg small middle doth, which is related to a long elimination half-life (t1/2beta=7.18 h and 6.70 h i.v. and i.m., respectively). Pharmacokinetic parameters were not significantly different between both routes of administration. Marbofloxacin was rapidly absorbed after i.m. administration (Tmax=0.9 h) and had high bioavailability (F=100.74%).

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Citations

Sep 15, 2009·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Olimpia R LaiElisa Escudero
Jun 3, 2006·American Journal of Veterinary Research·James W CarpenterDavid E Koch
Apr 2, 2009·American Journal of Veterinary Research·James W CarpenterRobert P Hunter
Feb 3, 2007·Journal of the American Veterinary Medical Association·Butch KuKanichMark G Papich
Nov 21, 2014·The Journal of Veterinary Medical Science·Sileshi BelewSeung-Chun Park
Mar 5, 2004·Journal of Veterinary Pharmacology and Therapeutics·S WaxmanC Rodríguez
Dec 7, 2017·Frontiers in Pharmacology·Zhixin LeiQigai He
Apr 15, 2014·Polish Journal of Veterinary Sciences·S YohannesS C Park
Jun 27, 2018·Journal of the South African Veterinary Association·Yigit KacarZafer Mecitoglu
Jun 1, 2012·Journal of Avian Medicine and Surgery·Marino Garcia-MontijanoSamanta Waxman
Jan 12, 2011·Journal of Veterinary Pharmacology and Therapeutics·L G YuanY H Liu
Sep 13, 2005·The Veterinary Journal·Marilyn MartinezRobert Walker

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