PMID: 15356995Sep 11, 2004Paper

Pharmacokinetic changes in drugs during protein-calorie malnutrition: correlation between drug metabolism and hepatic microsomal cytochrome P450 isozymes

Archives of Pharmacal Research
Joo Hyun LeeMyung G Lee

Abstract

The rats with protein-calorie malnutrition (PCM, 5% casein diet for a period of 4-week) were reported to exhibit 60 and 80% suppression in the hepatic microsomal cytochrome P450 (CYP) 1A2 and CYP2C11 levels, respectively, and 40-50% decreases in CYP2E1 and CYP3A1/2 levels compared to control (23% casein diet for a period of 4-week) based on Western blot analysis. In addition, Northern blot analysis showed that CYP1A2, CYP2E1, CYP2C11, and CYP3A1/2 mRNAs decreased in the state of PCM as well. Hence, pharmacokinetic changes of the drugs in rats with PCM [especially the area under the plasma concentration-time curve from time zero to time infinity (AUC) changes of metabolite(s)] reported from literatures were tried to explain in terms of CYP isozyme changes in the rats. Otherwise, the time-averaged nonrenal clearance (CL NR) of parent drug was compared. Pharmacokinetic changes of the drugs in other types of malnutritional state, such as kwashiorkor and marasmus, in both human and animal models were also compared. The drugs reviewed are as follows: diuretics, antibiotics, anticancer agents, antiepileptics, antiarrythmics, analgesics, xanthines, antimalarials, and miscellaneous.

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Citations

Mar 28, 2008·Pharmacotherapy·Lori B HornsbyAmy R Donaldson
Feb 9, 2012·The Journal of Pharmacy and Pharmacology·Ebtehal El-DemerdashFarid M A Hamada
Oct 6, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yu Kyung LeeYoung Hee Choi
Nov 10, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Young Hee ChoiMyung Gull Lee
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Aug 11, 2010·The Proceedings of the Nutrition Society·Joseph I Boullata
Feb 13, 2020·Journal of Biochemical and Molecular Toxicology·Wafaa R MohamedEbtehal Mohammad Fikry
Feb 23, 2020·Pediatric Blood & Cancer·John T Wiernikowski, Melanie Brooke Bernhardt
Feb 26, 2020·Pediatric Blood & Cancer·Paul C Rogers, Ronald D Barr
May 27, 2020·Journal of Nutrition and Metabolism·Weldegebrial Hayelom TedlaHaftom Gebrehiwot Weldearegay
Nov 25, 2016·Biomedical Reports·Adel AlkhedaideZein Shaban Ibrahim
Mar 29, 2013·Journal of Nutritional Science and Vitaminology·Kaori YokotaniKeizo Umegaki

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