Pharmacokinetic comparison of omeprazole capsules and a simplified omeprazole suspension

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
J C SongC M White

Abstract

The pharmacokinetics of omeprazole delayed-release capsules and a simplified omeprazole suspension (SOS) were studied. Seven healthy volunteers randomly received either one 20-mg omeprazole delayed-release capsule or SOS (omeprazole 20 mg in 10 mL) for seven days before being crossed over to the opposite treatment for seven more days after a two-week washout period. On days 1 and 7, blood samples were drawn at intervals up to 360 minutes after drug administration. Plasma omeprazole concentrations were determined by a validated high-performance liquid chromatographic method, and pharmacokinetic values were determined. Area under the concentration-versus-time curve (AUC) from zero to six hours, AUC from time zero to infinity (AUC0-infinity), and maximum plasma concentration (Cmax) increased by 102%, 113%, and 85%, respectively, after seven days of treatment with the capsule. AUC0-infinity for SOS on day 1 was 58% of that for the capsule (p = 0.0141), and on day 7 it was 49% of that for the capsule (p = 0.0044). AUC0-infinity for SOS increased by 85% from day 1 to 7, but the difference was not significant. Cmax for SOS on day 1 was twice that for the capsule (p = 0.0014), but by day 7 the difference between the two formulations wa...Continue Reading

Citations

Nov 2, 2005·Expert Opinion on Pharmacotherapy·Donald Castell
May 21, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·John W Devlin
Nov 24, 2005·Alimentary Pharmacology & Therapeutics·C W Howden
Nov 24, 2005·Alimentary Pharmacology & Therapeutics·J R Horn, C W Howden
Dec 17, 2008·Alimentary Pharmacology & Therapeutics·K M Olsen, J W Devlin
Jul 26, 2014·Expert Review of Pharmacoeconomics & Outcomes Research·Jayashri SankaranarayananKeith M Olsen
Nov 28, 2002·The Annals of Pharmacotherapy·Rose Jung, Robert MacLaren

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