Pharmacokinetic comparison of two nicotine transdermal systems, a 21-mg/24-hour patch and a 25-mg/16-hour patch: a randomized, open-label, single-dose, two-way crossover study in adult smokers

Clinical Therapeutics
Angela M DeVeaugh-GeissMichael J Durcan

Abstract

A comparison of the 21-mg NiQuitin patch with other marketed nicotine patches reported significant differences in pharmacokinetic profiles, even among patches of the identical labeled dose strength. The 25-mg Nicorette Invisi patch became available in the United Kingdom at the end of 2008. No published studies have directly compared the pharmacokinetic profile of this new patch with that of the 21-mg NiQuitin patch. This study was conducted to compare the single-dose pharmacokinetics of the 21-mg/24-hour patch and the 25-mg/16-hour patch. To determine whether any pharmacokinetic differences might be related to differences in wear time, a post hoc exploratory analysis evaluated the nicotine delivery profiles of the patches under the assumption that the 21-mg patch was removed after 16 rather than 24 hours. This was a single-center, randomized, open-label, single-dose, 2-way crossover study in healthy adults who smoked >10 cigarettes per day in the 6 months before the study. Eligible subjects were housed at the study center for 2 baseline and 2 treatment sessions; no smoking was permitted during the baseline or treatment sessions. Subjects were allocated to receive either the 21-mg patch (removed after 24 hours) or the 25-mg patc...Continue Reading

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Citations

Jan 25, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael K WongDaniel B Hardy
Jan 7, 2015·British Journal of Pharmacology·Michael N PastoreMichael S Roberts
Sep 11, 2012·Toxicology and Applied Pharmacology·Amanda K WoynillowiczAlison C Holloway
Jan 11, 2018·British Journal of Clinical Pharmacology·Ricardo Alvarez-JimenezGeert Jan Groeneveld
Jan 20, 2012·The Cochrane Database of Systematic Reviews·Amanda C FarleyPaul Aveyard
Nov 20, 2010·Zeitschrift für Gesundheitswissenschaften = Journal of public health·Ivana T CroghanCharles L Loprinzi
Dec 26, 2013·American Journal of Physiology. Endocrinology and Metabolism·A C HollowayN Alfaidy
Sep 29, 2020·Journal of Family Medicine and Primary Care·Rajkumari E DeviSreeparna Das
Jul 22, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Mahadevabharath R SomayajiLaurent Simon
Oct 7, 2021·The Cochrane Database of Systematic Reviews·Jamie Hartmann-BoycePaul Aveyard

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